钙通道阻滞剂对离体大鼠子宫不同类型平滑肌激活的影响。

The effect of calcium-channel-blocking agents on the various types of smooth muscle activation of the isolated rat uterus.

作者信息

Varagić V M, Milovanović S R, Srkalović G

出版信息

Arch Int Pharmacodyn Ther. 1984 Jul;270(1):79-87.

Abstract

Both verapamil and nifedipine were found to inhibit various types of activation of the isolated rat uterus, as for example: tonic and phasic components of contraction produced by KC1 and by oxytocin, phasic components of contraction produced by electrical stimulation and phasic spontaneous rhythmic activity. Presumably, verapamil and nifedipine affect a common pathway in calcium metabolism in all three types of muscle activation. Both verapamil and nifedipine inhibited more the contractile responses to high concentrations of KC1 than the responses to oxytocin, indicating the possibility of KCI and oxytocin acting through different calcium channels. Nifedipine inhibited more the tonic than phasic components of contractions produced by both KCI and oxytocin. It is assumed that two different calcium channels might be implicated in two components of contractions produced by KCI and oxytocin. Phasic components of contraction produced by KCI and by electrical stimulation were almost completely restored by increasing the concentration of calcium in the medium, whereas tonic components were restored only to about 50%.

摘要

维拉帕米和硝苯地平均被发现可抑制离体大鼠子宫的各种类型的激活，例如：由氯化钾和催产素产生的收缩的强直和相性成分、电刺激产生的收缩的相性成分以及相性自发节律活动。据推测，维拉帕米和硝苯地平在所有三种肌肉激活类型中影响钙代谢的共同途径。维拉帕米和硝苯地平对高浓度氯化钾的收缩反应的抑制作用比对催产素反应的抑制作用更强，这表明氯化钾和催产素可能通过不同的钙通道起作用。硝苯地平对由氯化钾和催产素产生的收缩的强直成分的抑制作用比对相性成分的抑制作用更强。据推测，两种不同的钙通道可能与由氯化钾和催产素产生的收缩的两个成分有关。通过增加培养基中钙的浓度，由氯化钾和电刺激产生的收缩的相性成分几乎完全恢复，而强直成分仅恢复到约50%。