Nowak Jan K, Grulkowski Ireneusz, Karnowski Karol, Wojtkowski Maciej, Walkowiak Jaroslaw
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, ul. Szpitalna 27/33, 60-572 Poznan, Poland.
Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, ul. Grudziadzka 5, 87-100 Torun, Poland.
PLoS One. 2015 Jan 26;10(1):e0117517. doi: 10.1371/journal.pone.0117517. eCollection 2015.
The labial minor salivary glands (LSGs) are easily accessible mucus-secreting structures of the alimentary tract that may provide new information on the basis of gastrointestinal complications of cystic fibrosis (CF). It was shown that they are destructed in the course of cystic fibrosis. We employed wide-field, micrometer resolution in vivo optical coherence tomography to assess the surface density of LSGs in 18 patients with CF and 18 healthy subjects. The median LSGs' surface densities in CF patients, and in the control group were 4.32 glands/cm2 and 6.58 glands/cm2, respectively (p = 0.006; Mann-Whitney U test). A lower LSG surface density is a previously unrecognized CF-related pathology of the alimentary tract.
唇小唾液腺（LSGs）是消化道中易于获取的黏液分泌结构，可能会为囊性纤维化（CF）的胃肠道并发症提供新的信息。研究表明，它们在囊性纤维化过程中会遭到破坏。我们采用宽视野、微米级分辨率的体内光学相干断层扫描技术，评估了18例CF患者和18名健康受试者的唇小唾液腺表面密度。CF患者和对照组唇小唾液腺的表面密度中位数分别为4.32个腺体/平方厘米和6.58个腺体/平方厘米（p = 0.006；曼-惠特尼U检验）。较低的唇小唾液腺表面密度是一种先前未被认识到的与CF相关的消化道病理表现。
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