Reyna-Figueroa Jesús, Lagunas-Martínez Alfredo, Martínez Matsumoto Pilar, Madrid-Marina Vicente
Programa de Doctorado en Ciencias de la Salud, concentración en Enfermedades Infecciosas.
Instituto Nacional de Salud Pública, Centro de Investigación sobre Enfermedades Infecciosas.
Arch Argent Pediatr. 2015 Jan;113(1):46-52. doi: 10.5546/aap.2015.46.
Among cancer and septic patients, there is a deregulation of common events such as inflammation. This fact limits the use of biomarkers to diagnose sepsis. Through a search in the PubMed database, we identified the clinical studies that evaluated procalcitonin as a biomarker among children with cancer and sepsis; we analyzed its characteristics, advantages and disadvantages. Most of the studies suggest that with a cut-off point between 0.5 ng/dl and 1 mg/dl, procalcitonin displays a sensitivity of 59-78%, a specificity of 76%, a predictive value of 93% and a negative predictive value of 45% to diagnose sepsis. The procalcitonin values were not modified by the use of chemotherapy or steroids. In the past few years, encouraging results have been obtained when using it as a biomarker in children with cancer, particularly with neutropenia and fever.
在癌症患者和脓毒症患者中，存在诸如炎症等常见事件的失调。这一事实限制了生物标志物在诊断脓毒症方面的应用。通过在PubMed数据库中检索，我们确定了评估降钙素原作为癌症和脓毒症儿童生物标志物的临床研究；我们分析了其特征、优缺点。大多数研究表明，当截断值在0.5 ng/dl至1 mg/dl之间时，降钙素原诊断脓毒症的敏感性为59 - 78%，特异性为76%，预测值为93%，阴性预测值为45%。降钙素原的值不会因化疗或类固醇的使用而改变。在过去几年中，将其用作癌症儿童尤其是中性粒细胞减少和发热儿童的生物标志物时，已取得了令人鼓舞的结果。
