子宫内膜癌的突变图谱。
The mutational landscape of endometrial cancer.
作者信息
Hong Bo, Le Gallo Matthieu, Bell Daphne W
机构信息
Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Curr Opin Genet Dev. 2015 Feb;30:25-31. doi: 10.1016/j.gde.2014.12.004. Epub 2015 Jan 23.
Abstract
Globally, endometrial carcinoma causes about 74000 deaths annually. Endometrial carcinomas can be classified into several histological subtypes including endometrioid and serous histologies. Over the course of the past two years, a number of studies have decoded the exomes of endometrioid and serous endometrial carcinomas revealing novel somatically mutated genes that are likely to drive their development. Moreover, an integrated genomic analysis of these two histological subtypes by The Cancer Genome Atlas has led to their molecular reclassification into four discrete molecular subgroups. Collectively, these genomic advances set the stage for future biological and clinical studies to determine their relevance for patient care.
摘要
在全球范围内，子宫内膜癌每年导致约74000人死亡。子宫内膜癌可分为几种组织学亚型，包括子宫内膜样和浆液性组织学类型。在过去两年中，多项研究对子宫内膜样和浆液性子宫内膜癌的外显子组进行了解码，揭示了可能驱动其发展的新的体细胞突变基因。此外，癌症基因组图谱对这两种组织学亚型进行的综合基因组分析，已导致它们在分子水平上重新分类为四个不同的分子亚组。总体而言，这些基因组学进展为未来的生物学和临床研究奠定了基础，以确定它们与患者护理的相关性。
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