Nordenström B E
Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden.
Physiol Chem Phys Med NMR. 1989;21(4):249-55; discussion 255-6.
In experiments on rats, a hind leg was transected except for the femoral nerve, artery and vein. The femoral nerve was stimulated by electrical pulses, with one electrode attached to the nerve in the amputation gap and another placed in the inferior caval vein. At each pulse of stimulation, contraction could be recorded in femoral muscles. Ligation of the femoral vessels suspended the contractions within a fraction of a second; contractions resumed when ligation ended. Propagation of neural stimuli to femoral muscles therefore required an intact electrical communication through associated vessels. This is possible because conducting blood plasma and its capillary junction with the interstitial fluid form an "external" closed circuit branch of low resistance with the neuromuscular unit. In testing the interstitial tissue fluid as an alternative to the vascular "outer" communication, a higher voltage of stimulation was required for muscle contractions.
在对大鼠的实验中，除股神经、动脉和静脉外，切断其后腿。用电脉冲刺激股神经，一个电极连接到截肢间隙的神经上，另一个电极置于下腔静脉中。在每次刺激脉冲时，可记录到股部肌肉的收缩。结扎股血管会在几分之一秒内使收缩停止；结扎结束时收缩恢复。因此，神经刺激向股部肌肉的传导需要通过相关血管进行完整的电连通。这是可能的，因为传导性血浆及其与组织液的毛细血管连接形成了与神经肌肉单元相连的低电阻“外部”闭合回路分支。在测试组织间隙液作为血管“外部”连通的替代物时，肌肉收缩需要更高的刺激电压。
