硒代半胱氨酸的掺入：mRNA 降解游戏中的一张王牌。
Selenocysteine incorporation: A trump card in the game of mRNA decay.
作者信息
Shetty Sumangala P, Copeland Paul R
机构信息
Department of Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, 675 Hoes Ln, Piscataway, NJ 08854, USA.
Department of Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, 675 Hoes Ln, Piscataway, NJ 08854, USA.
出版信息
Biochimie. 2015 Jul;114:97-101. doi: 10.1016/j.biochi.2015.01.007. Epub 2015 Jan 23.
Abstract
The incorporation of the 21st amino acid, selenocysteine (Sec), occurs on mRNAs that harbor in-frame stop codons because the Sec-tRNA(Sec) recognizes a UGA codon. This sets up an intriguing interplay between translation elongation, translation termination and the complex machinery that marks mRNAs that contain premature termination codons for degradation, leading to nonsense mediated mRNA decay (NMD). In this review we discuss the intricate and complex relationship between this key quality control mechanism and the process of Sec incorporation in mammals.
摘要
第21种氨基酸硒代半胱氨酸（Sec）的掺入发生在含有框内终止密码子的mRNA上，因为硒代半胱氨酸转运RNA（Sec-tRNA(Sec)）识别UGA密码子。这在翻译延伸、翻译终止以及标记含有提前终止密码子的mRNA进行降解的复杂机制之间建立了一种有趣的相互作用，导致无义介导的mRNA降解（NMD）。在这篇综述中，我们讨论了这种关键的质量控制机制与哺乳动物中硒代半胱氨酸掺入过程之间复杂而微妙的关系。
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