Freudenthal Nelly, Sternudd Mika, Jansson Leif, Wannfors Karin
Eastman Institute Maxillofacial Surgery, Public Dental Service, Stockholm County Council, Stockholm, Sweden.
Public Dental Service, Gotland County, Visby, Sweden.
J Oral Maxillofac Surg. 2015 Apr;73(4):600-5. doi: 10.1016/j.joms.2014.08.035. Epub 2014 Sep 16.
The main purpose of the present investigation was to determine whether intra-alveolar chlorhexidine (CHX) gel is an effective preventative treatment for alveolar osteitis (AO), as has been strongly suggested by previous investigators. Another goal was to evaluate whether there is a correlation between the use of analgesics during the postoperative week and the development of AO, a correlation that could be a supplement to the commonly used diagnostic criteria for AO.
A double-blinded randomized study was performed to assess whether intra-alveolar administration of CHX decreases AO. To achieve this objective, the extraction and postoperative course of 100 impacted mandibular third molars were studied. Ninety-seven percent of teeth operated on had a diagnosed pathology. The extraction alveoli were treated with CHX or placebo. The intake of analgesics was recorded for 7 days after the operation.
Statistically important differences in AO between the control and experimental groups were not found. The intake of analgesics reflected the occurrence of AO with a high degree of importance.
The present study did not verify that application of CHX gel improves healing after removal of impacted third molars. The patients' postoperative analgesic intake reflected the development of AO.
本研究的主要目的是确定牙槽窝内应用氯己定（CHX）凝胶是否如先前研究者强烈建议的那样，是一种治疗干槽症（AO）的有效预防性措施。另一个目标是评估术后一周内镇痛药的使用与干槽症的发生之间是否存在相关性，这种相关性可能是对常用的干槽症诊断标准的补充。
进行了一项双盲随机研究，以评估牙槽窝内应用CHX是否能降低干槽症的发生率。为实现这一目标，对100颗下颌阻生第三磨牙的拔除及术后过程进行了研究。接受手术的牙齿中有97%被诊断患有病变。拔牙窝用CHX或安慰剂进行处理。术后7天记录镇痛药的摄入量。
未发现对照组和实验组在干槽症方面有统计学上的显著差异。镇痛药的摄入量在很大程度上反映了干槽症的发生情况。
本研究未证实应用CHX凝胶能改善阻生第三磨牙拔除后的愈合情况。患者术后镇痛药的摄入量反映了干槽症的发生情况。
