Department of Stomatology. Faculty of Dentistry. University of Granada, Spain.
Med Oral Patol Oral Cir Bucal. 2013 Jul 1;18(4):e693-700. doi: 10.4317/medoral.18702.
Alveolar osteitis (AO) is the most common postoperative complication of dental extractions. The purpose of this study was to compare the effectiveness of 1% versus 0.2% chlorhexidine (CHX) gel in reducing postoperative AO after surgical extraction of mandibular third molars, and assess the impact of treatment on the Oral HealthRelated Quality of Life (OHRQoL).
This clinical study was a randomized, double-blind clinical trial. Eighty eight patients underwent surgical extraction of one retained mandibular third molar with the intra-alveolar application of 0.2% CHX gel. Afterwards, they were assigned to one of two groups: 1% CHX gel (n=42) or 0.2% CHX gel (n=46). The patients applied the gel twice a day to the wound for one week. All patients were evaluated for AO.
In the 0.2% CHX gel group, 13% of AO incidence was found, while in the 1% CHX gel group, AO incidence was 7%, a difference that was not statistically significant. Variables such as sensation of pain and inflammation at baseline and during one week, as well as OHRQoL of the patients at 24 hours and 7 days post-extraction, gave no statistically significant differences.
There are no significant differences in AO after surgical extraction of mandibular third molars, when comparing applying 1% CHX gel twice a day for 7 days with 0.2% CHX gel.
牙槽炎（AO）是拔牙术后最常见的并发症。本研究旨在比较 1%洗必泰（CHX）凝胶与 0.2%洗必泰凝胶在减少下颌第三磨牙拔除术后 AO 方面的效果，并评估治疗对口腔健康相关生活质量（OHRQoL）的影响。
这是一项随机、双盲的临床研究。88 名患者接受了下颌第三磨牙的手术拔除，牙槽内应用 0.2%CHX 凝胶。之后，他们被分配到两组中的一组：1%CHX 凝胶（n=42）或 0.2%CHX 凝胶（n=46）。患者每天两次将凝胶涂抹在伤口上，持续一周。所有患者均评估了 AO。
在 0.2%CHX 凝胶组中，发现 13%的 AO 发生率，而在 1%CHX 凝胶组中，AO 发生率为 7%，差异无统计学意义。基线和一周内疼痛和炎症感觉等变量，以及患者在拔牙后 24 小时和 7 天的 OHRQoL，均无统计学差异。
在比较每天两次使用 1%CHX 凝胶 7 天与 0.2%CHX 凝胶在减少下颌第三磨牙拔除术后 AO 方面，没有显著差异。
