Pérez Castrillón J L, Pérez Arellano J L, García Palomo J D, Martín Rodríguez M, Jiménez López A
An Med Interna. 1989 Jul;6(7):351-4.
Intravenous (I.V.) drug users possess a decrease of the monocyte chemotaxis directly related to drug usage. We study the effects of naloxone on monocyte chemotaxis in I.V. drug users, evaluating the chemotactic index and the cellular level of cAMP. The incubation of monocytes with naloxone did not modify the chemotactic index nor the cellular levels of cAMP, the first remaining low and the second high, this being statistically significant compared with the control group. We comment on the possible causes of naloxone's lack of effect and we suggest the role of cAMP in causing the chemotactic defect in this group of patients.
静脉注射吸毒者的单核细胞趋化性降低，且这一降低与药物使用直接相关。我们研究了纳洛酮对静脉注射吸毒者单核细胞趋化性的影响，评估了趋化指数和环磷酸腺苷（cAMP）的细胞水平。用纳洛酮孵育单核细胞并未改变趋化指数，也未改变cAMP的细胞水平，前者仍然较低，后者仍然较高，与对照组相比，这具有统计学意义。我们讨论了纳洛酮缺乏效果的可能原因，并提出了cAMP在导致该组患者趋化缺陷中的作用。
