Gungor Sinem, Ozseker Ferhan, Yalcinsoy Murat, Akkaya Esen, Can Günay, Eroglu Hacer, Genc Nilgün Sema
Sureyyapasa Chest Diseases and Chest Surgery Training Hospital, Department of Chest Diseases, Istanbul, Turkey.
Sureyyapasa Chest Diseases and Chest Surgery Training Hospital, Department of Immunology and Allergy, Istanbul, Turkey.
Int Immunopharmacol. 2015 Mar;25(1):174-9. doi: 10.1016/j.intimp.2015.01.015. Epub 2015 Jan 23.
Currently, there are no objective criteria to determine sarcoidosis activity. The present study aimed to discover a sensitive serum marker that would determine the activity of sarcoidosis and can be used during disease follow-up.
Forty-eight patients with sarcoidosis and twenty healthy volunteers as a control group were included in the study. On their control visits, the patients were divided into active and inactive groups based on their clinical, physiological, and radiological status. Angiotensin converting enzyme (ACE), adenosine deaminase (ADA), total IgE (T-IgE), C-reactive protein (CRP), serum amyloid-A (SAA), and soluble interleukin-2 receptor (sIL2R) serum levels and classical findings of activity were compared, and the utilization of these parameters as markers of activity was investigated.
Thirty-nine cases were female (female/male: 39/9) and the mean age was 44.29±10.9years. Thirty-seven cases were active and 11 cases were inactive. Serum ACE, ADA, sIL2R, and SAA levels were significantly higher while T-IgE levels were lower in the sarcoidosis cases. A comparison of the markers between active and inactive cases showed that only SAA was significantly higher (p<0.001). sIL2R was elevated in cases with extra-pulmonary involvement (p<0.014). The area under the curve value was rather high for ADA (0.98 CI: 0.96-1.0); it also had high sensitivity (93.8%) and specificity (100%), and therefore had the highest diagnostic value (96.6%).
The current study showed that SAA wil be helpfull for detecting the activity of srcoidosis, IL2R measurement in exploring the extra-pulmonary organ involvement.
目前，尚无确定结节病活动度的客观标准。本研究旨在发现一种敏感的血清标志物，用于确定结节病的活动度，并可在疾病随访期间使用。
本研究纳入了48例结节病患者和20名健康志愿者作为对照组。在对照访视时，根据患者的临床、生理和放射学状态将其分为活动组和非活动组。比较血管紧张素转换酶（ACE）、腺苷脱氨酶（ADA）、总IgE（T-IgE）、C反应蛋白（CRP）、血清淀粉样蛋白A（SAA）和可溶性白细胞介素-2受体（sIL2R）的血清水平以及活动的经典表现，并研究这些参数作为活动标志物的应用。
39例为女性（女/男：39/9），平均年龄为44.29±10.9岁。37例为活动期，11例为非活动期。结节病患者的血清ACE、ADA、sIL2R和SAA水平显著升高，而T-IgE水平较低。活动期和非活动期病例之间的标志物比较显示，只有SAA显著更高（p<0.001）。肺外受累病例的sIL2R升高（p<0.014）。ADA的曲线下面积值相当高（0.98 CI：0.96-1.0）；它还具有高敏感性（93.8%）和特异性（100%），因此具有最高的诊断价值（96.6%）。
当前研究表明，SAA有助于检测结节病的活动度，IL2R测量有助于探索肺外器官受累情况。
