[内源性葡萄膜炎患者血清腺苷脱氨酶和血管紧张素转换酶活性]

[Serum adenosine deaminase and angiotensin converting enzyme activity in patients with endogenous uveitis].

作者信息

Fukami R, Ohba S, Ishida K, Nakamura S, Konno M, Ohno S

机构信息

Department of Ophthalmology, Yokohama City University School of Medicine, Japan.

出版信息

Nippon Ganka Gakkai Zasshi. 1994 Mar;98(3):287-92.

PMID:8154388

Abstract

Serum activity of adenosine deaminase (ADA) and angiotensin converting enzyme (ACE) was investigated in 32 patients with sarcoidosis, 22 patients with Behçet's disease, 22 patients with Vogt-Koyanagi-Harada's (VKH) disease and 253 healthy controls. In healthy controls, the ADA level was significantly higher in females than in males (p < 0.01). In patients with sarcoidosis, the serum ADA level was significantly higher in both males and females than in the controls (p < 0.01). In patients with Behçet's disease, the serum ADA level was significantly higher than in the controls (p < 0.01) in males only. In VKH disease, the serum ADA level showed no significant difference from the normal controls. Significant elevation of the serum ACE activity was observed only in patients with sarcoidosis (p < 0.01). Serum ACE activity was therefore considered to be more specific to sarcoidosis than serum ADA activity.

摘要

对32例结节病患者、22例白塞病患者、22例Vogt-小柳原田病（VKH病）患者和253名健康对照者的血清腺苷脱氨酶（ADA）和血管紧张素转换酶（ACE）活性进行了研究。在健康对照者中，女性的ADA水平显著高于男性（p<0.01）。在结节病患者中，男性和女性的血清ADA水平均显著高于对照组（p<0.01）。在白塞病患者中，仅男性的血清ADA水平显著高于对照组（p<0.01）。在VKH病中，血清ADA水平与正常对照组无显著差异。仅在结节病患者中观察到血清ACE活性显著升高（p<0.01）。因此，血清ACE活性被认为比血清ADA活性对结节病更具特异性。