Factors affecting ¹⁸F FDOPA standardized uptake value in patients with primary brain tumors after treatment.

作者信息

Chiaravalloti Agostino, Fiorentini Alessandro, Villani Veronica, Carapella Carmine, Pace Andrea, Di Pietro Barbara, Di Russo Carmen, Palumbo Barbara, Floris Roberto, Schillaci Orazio

机构信息

Department of Biomedicine and Prevention, University Tor Vergata of Rome, Italy.

出版信息

Nucl Med Biol. 2015 Apr;42(4):355-9. doi: 10.1016/j.nucmedbio.2015.01.002. Epub 2015 Jan 9.

AIM

To investigate the factors affecting (18)F FDOPA uptake in patients with primary brain tumors (PBT) after treatment.

MATERIALS AND METHODS

97 patients with PBT (6 were grade I, 40 were grade II, 29 were grade III and 22 were grade IV) underwent (18)F FDOPA positron emission tomography/computed tomography (PET/CT) after treatment. Intervals from surgery, chemotherapy (CHT) and radiotherapy (RT) were 41.48 (±42.27), 16.04 (±29.08) and 28.62 (±34.49) months respectively.

RESULTS

(18)F FDOPA uptake in the site of recurrence was not related to the interval from surgery and CHT while a significant relationship has been found with the interval from RT and tumor grade.

CONCLUSIONS

The results of our study show that the interval from RT and the grade of PBT should be considered carefully when evaluating brain PET/CT scans since these factors could directly affect (18)F FDOPA uptake.