Ahmed Nizar, Parthasarathy Harinath, Arshad Mohamed, Victor Dhayanand John, Mathew Danny, Sankari Siva
Department of Periodontics, Thai Moogambigai Dental College, Chennai, Tamil Nadu, India.
Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India.
J Indian Soc Periodontol. 2014 Nov-Dec;18(6):728-33. doi: 10.4103/0972-124X.147408.
To compare and quantify the presence of periodontal pathogens Aggregatibacter actinomycetemcomitans (Aac) and Porphyromonas gingivalis (Pg) in Down's syndrome (DS) and systemically healthy subjects with periodontitis and gingivitis.
Fifty-nine age-matched subjects were categorized into four groups; Group I: DS subjects with gingivitis, Group II: DS subjects with periodontitis, Group III: Systemically healthy subjects with gingivitis and Group IV: Systemically healthy subjects with periodontitis. Plaque samples from all the four groups were collected and analyzed to evaluate the presence of Aac and Pg using real time polymerase chain reaction. The indices used were oral hygiene index simplified, community periodontal index for treatment needs and plaque index.
This study showed a statistically significant detection in the levels of both Aac (<0.001) and Pg (<0.001) in DS subjects with periodontitis when compared with the healthy controls with periodontitis; moreover, there was a statistically significant increase in Pg levels compared to Aac in DS gingivitis group.
There was a statistically significant presence of Pg and Aac in both DS gingivitis and DS periodontitis over control groups with increased levels of Pg compared with Aac in DS gingivitis group.
比较并量化唐氏综合征（DS）患者以及患有牙周炎和牙龈炎的全身健康受试者中牙周病原体伴放线聚集杆菌（Aac）和牙龈卟啉单胞菌（Pg）的存在情况。
59名年龄匹配的受试者被分为四组；第一组：患有牙龈炎的DS患者；第二组：患有牙周炎的DS患者；第三组：患有牙龈炎的全身健康受试者；第四组：患有牙周炎的全身健康受试者。收集并分析所有四组的菌斑样本，使用实时聚合酶链反应评估Aac和Pg的存在情况。所使用的指数为简化口腔卫生指数、治疗需要的社区牙周指数和菌斑指数。
本研究表明，与患有牙周炎的健康对照组相比，患有牙周炎的DS患者中Aac（<0.001）和Pg（<0.001）水平的检测具有统计学意义；此外，与DS牙龈炎组中的Aac相比，Pg水平有统计学意义的升高。
与对照组相比，DS牙龈炎和DS牙周炎中Pg和Aac的存在具有统计学意义，且DS牙龈炎组中Pg水平高于Aac。
