Barr-Agholme M, Dahllöf G, Linder L, Modéer T
Karolinska Institute, Huddinge, Sweden.
Oral Microbiol Immunol. 1992 Aug;7(4):244-8. doi: 10.1111/j.1399-302x.1992.tb00033.x.
Levels of Actinobacillus actinomycetemcomitans, Capnocytophaga and Porphyromonas gingivalis were determined in subgingival plaque samples from 37 adolescents with Down's syndrome and 37 healthy controls matched with respect to age and sex. Gingival inflammation, supra- and subgingival calculus, periodontal pockets ( > 4 mm) and alveolar bone loss were registered. Alveolar bone loss was more frequent in Down's syndrome subjects (32%) than in the controls (3%). A. actinomycetemcomitans was detected in the subgingival plaque in 35% of the Down's syndrome adolescents and in 5% of the controls. On site level, A. actinomycetemcomitans and Capnocytophaga were more frequent in the subgingival plaque samples of Down's syndrome children than in those of controls. Comparing Down's syndrome subjects positive or negative for A. actinomycetemcomitans and Capnocytophaga, no significant differences were found in terms of gingival inflammation, periodontal pockets ( > 4 mm) or number of sites with alveolar bone loss. The results indicate an altered microbial composition of the subgingival plaque of Down's syndrome subjects compared with healthy controls, with higher frequency of A. actinomycetemcomitans.
在37名患有唐氏综合征的青少年以及37名年龄和性别相匹配的健康对照者的龈下菌斑样本中，检测了伴放线放线杆菌、二氧化碳嗜纤维菌和牙龈卟啉单胞菌的水平。记录了牙龈炎症、龈上和龈下牙结石、牙周袋（>4mm）和牙槽骨吸收情况。唐氏综合征患者中牙槽骨吸收更为常见（32%），而对照组中为3%。在35%的唐氏综合征青少年龈下菌斑中检测到伴放线放线杆菌，而对照组中为5%。在菌斑位点水平上，唐氏综合征儿童龈下菌斑样本中伴放线放线杆菌和二氧化碳嗜纤维菌比对照组更为常见。比较伴放线放线杆菌和二氧化碳嗜纤维菌阳性或阴性的唐氏综合征患者，在牙龈炎症、牙周袋（>4mm）或牙槽骨吸收位点数量方面未发现显著差异。结果表明，与健康对照相比，唐氏综合征患者龈下菌斑的微生物组成发生了改变，伴放线放线杆菌的出现频率更高。
