Liu Lingjuan, Mao Dingan, Liu Liqun, Huang Yu, Bo Tao
Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Neural Regen Res. 2012 Sep 15;7(26):2036-42. doi: 10.3969/j.issn.1673-5374.2012.26.005.
Seizures were induced by flurothyl inhalation. Rats were intramuscularly treated with progesterone after each seizure. Results demonstrated that glutamate transporter 2 and γ-aminobutyric acid transporter 1 expression levels were significantly increased in the cerebral cortex and hippocampus of the developing rat brain following recurrent seizures. After progesterone treatment, glutamate transporter 2 protein expression was upregulated, but γ-aminobutyric acid transporter 1 levels decreased. These results suggest that glutamate transporter 2 and γ-aminobutyric acid transporter 1 are involved in the pathological processes of epilepsy. Progesterone can help maintain a balance between excitatory and inhibitory systems by modulating the amino acid transporter system, and protect the developing brain after recurrent seizures.
通过吸入氟烷诱导癫痫发作。每次癫痫发作后，对大鼠进行肌肉注射孕酮治疗。结果表明，反复癫痫发作后，发育中大鼠大脑的大脑皮层和海马体中谷氨酸转运体2和γ-氨基丁酸转运体1的表达水平显著增加。孕酮治疗后，谷氨酸转运体2蛋白表达上调，但γ-氨基丁酸转运体1水平下降。这些结果表明，谷氨酸转运体2和γ-氨基丁酸转运体1参与了癫痫的病理过程。孕酮可通过调节氨基酸转运体系统来帮助维持兴奋和抑制系统之间的平衡，并在反复癫痫发作后保护发育中的大脑。
