Michele Salemi, Salluzzo Maria Grazia, Calogero Aldo E, Raffaele Ferri, Bosco Paolo
IRCCS Associazione Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Italy.
Section of Endocrinology, Andrology and Internal Medicine, Department of Medical and Pediatric Sciences, University of Catania, Catania, Italy.
Arch Med Sci. 2014 Dec 22;10(6):1235-8. doi: 10.5114/aoms.2014.47832.
Alzheimer's disease (AD) is characterized by progression of memory problems to a slow global decline of cognitive function. Inflammation when left unregulated becomes a major cofactor in the pathogenesis of AD. PTGS2 is of crucial relevance in the inflammatory response, and it has been shown to play a considerable role in AD pathogenesis.
To assess the possible putative role of a PTGS2 polymorphism (-765 G/C) in AD patients, we examined, by pyrosequencing, its distribution in 84 Sicilian AD patients and in 80 controls.
No significant statistical difference in PTGS2 -765 G/C genotype distribution was found comparing patients with AD and controls. In addition, no significant difference was observed in the distribution of the PTGS2 -765 alleles between AD patients and controls.
These findings suggest that the PTGS2 -765 G/C polymorphism may not be associated with AD in the Sicilian population.
阿尔茨海默病（AD）的特征是记忆问题逐渐发展为认知功能的缓慢全面衰退。炎症若不受调控，会成为AD发病机制中的一个主要辅助因素。PTGS2在炎症反应中至关重要，并且已证明它在AD发病机制中发挥重要作用。
为评估PTGS2基因多态性（-765 G/C）在AD患者中可能的假定作用，我们通过焦磷酸测序法检测了其在84名西西里岛AD患者和80名对照中的分布情况。
比较AD患者和对照，PTGS2 -765 G/C基因型分布未发现显著统计学差异。此外，AD患者和对照之间PTGS2 -765等位基因的分布也未观察到显著差异。
这些发现表明，在西西里岛人群中，PTGS2 -765 G/C多态性可能与AD无关。
