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成人肝海绵状血管瘤伴甲胎蛋白高度升高:一例报告并文献复习

Adult hepatic cavernous hemangioma with highly elevated α-fetoprotein: A case report and review of the literature.

作者信息

Wang Huan-Yu, Zhang Liang, Wu Jian, Zhang Zi-Jian, Peng Bao-Gang, Liang Li-Jian, Zhou Qi

机构信息

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China.

Diagnostic Imaging and Interventional Radiology Department, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China.

出版信息

Oncol Lett. 2015 Feb;9(2):637-640. doi: 10.3892/ol.2014.2769. Epub 2014 Dec 4.

DOI:10.3892/ol.2014.2769
PMID:25624892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4301549/
Abstract

A 47-year-old male presented with a six-month history of fatigue and a four-month history of alanine and aspartate aminopherase elevation. Laboratory examination revealed that the serum α-fetoprotein (AFP) level was 371.51 μg/l (normal range, 0-20 μg/l), and a computed tomography scan revealed a hypodense lesion in the left hepatic lobe. During laparotomy, a dark red-colored soft tumor (1.5×1.7 cm in diameter) was found in segment eight of the liver. Intra-operative pathology and post-operative histopathology examinations revealed that the tumor was a hepatic cavernous hemangioma. The serum AFP level was decreased to 24.45 μg/l by the second post-operative week. The literature was searched and only three similar cases were found. A brief review of this rare disease entity was produced, which attempted to explain this appearance reasonably.

摘要

一名47岁男性,有6个月的疲劳病史以及4个月的丙氨酸和天冬氨酸转氨酶升高病史。实验室检查显示血清甲胎蛋白(AFP)水平为371.51μg/l(正常范围0 - 20μg/l),计算机断层扫描显示肝左叶有一个低密度病变。剖腹手术中,在肝脏VIII段发现一个暗红色软肿瘤(直径1.5×1.7cm)。术中病理及术后组织病理学检查显示该肿瘤为肝海绵状血管瘤。术后第二周血清AFP水平降至24.45μg/l。检索文献仅发现3例类似病例。对这一罕见疾病实体进行了简要综述,试图合理解释这种表现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aa0/4301549/11bf9d36086f/OL-09-02-0637-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aa0/4301549/5fa702eab3d0/OL-09-02-0637-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aa0/4301549/8383156a7856/OL-09-02-0637-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aa0/4301549/11bf9d36086f/OL-09-02-0637-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aa0/4301549/5fa702eab3d0/OL-09-02-0637-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aa0/4301549/8383156a7856/OL-09-02-0637-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aa0/4301549/11bf9d36086f/OL-09-02-0637-g02.jpg

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本文引用的文献

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Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association.血清肿瘤标志物对胃癌的临床意义:日本胃癌协会工作组的文献系统评价。
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Value of α-fetoprotein in association with clinicopathological features of hepatocellular carcinoma.甲胎蛋白与肝癌临床病理特征的关系价值。
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Hepatitis C genotype 4 with normal transaminases: correlation with fibrosis and response to treatment, a cohort Egyptian study of 4277 patients.
丙型肝炎基因型 4 伴正常转氨酶:与纤维化及治疗应答的相关性,一项针对 4277 例埃及患者的队列研究。
Clin Res Hepatol Gastroenterol. 2013 Nov;37(5):479-84. doi: 10.1016/j.clinre.2013.02.009. Epub 2013 Mar 26.
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Clinical and pathological features of hepatoid carcinoma of the ovary.卵巢肝样细胞癌的临床与病理特征。
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Synchronous presentation of hepatoid alpha-fetoprotein-producing lung cancer and colorectal adenocarcinoma.同时出现肝样甲胎蛋白生成性肺癌和结肠直肠腺癌
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Elevated serum levels of Chromogranin A in hepatocellular carcinoma.肝细胞癌患者血清嗜铬粒蛋白A水平升高。
BMC Surg. 2012;12 Suppl 1(Suppl 1):S7. doi: 10.1186/1471-2482-12-S1-S7. Epub 2012 Nov 15.
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An overview of biomarkers for the diagnosis of hepatocellular carcinoma.肝细胞癌诊断生物标志物概述
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