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涎腺嗜酸性细胞癌合并胸腺瘤:一例报告并文献复习

Oncocytic carcinoma of the salivary gland with thymoma: A case report and review of the literature.

作者信息

Cao Yongcheng, Zhu Ming, Mao Ruiqi, Cao Ruixue, Yu Guoli, Niu Aijun

机构信息

Department of Pathology, General Hospital of Jinan Military Command, Jinan, Shandong 250031, P.R. China.

Department of Radiology, General Hospital of Jinan Military Command, Jinan, Shandong 250031, P.R. China.

出版信息

Oncol Lett. 2015 Feb;9(2):681-684. doi: 10.3892/ol.2014.2707. Epub 2014 Nov 19.

Abstract

Oncocytic carcinoma (OC) arising in the salivary gland is a very rare tumor with only 32 previously reported cases. In this report, we describe a novel case of oncocytic carcinoma with associated thymoma, which arose in the left parotid gland of a 66-year-old male with a history of a painless left parotid mass for 1 year. Oncocytes are large, polygonal cells that are characterized by marked cellular atypia, frequent mitoses, wide eosinophilic granular cytoplasm, a central nucleus and a prominent nucleolus. The follow-up data showed no evidence of recurrence and the patient is in a good health 20 months after the surgery. In the current case, the patient had not only OC but also thymoma, which is exceedingly rare and may represent the first documented case in the literature.

摘要

涎腺发生的嗜酸性细胞癌(OC)是一种非常罕见的肿瘤,此前仅有32例报道。在本报告中,我们描述了一例伴有胸腺瘤的嗜酸性细胞癌新病例,该病例发生在一名66岁男性的左腮腺,患者有左侧腮腺无痛性肿块病史1年。嗜酸性细胞是大的多角形细胞,其特征为明显的细胞异型性、频繁的有丝分裂、宽阔的嗜酸性颗粒状细胞质、一个中央核和一个突出的核仁。随访数据显示无复发迹象,患者术后20个月健康状况良好。在本例中,患者不仅患有嗜酸性细胞癌,还患有胸腺瘤,这极为罕见,可能是文献中首例有记录的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3818/4301545/7227e38a3c41/OL-09-02-0681-g00.jpg

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