硫氰酸钾作为叔胺氧化α-氰化反应中氰化物的来源。
Potassium thiocyanate as source of cyanide for the oxidative α-cyanation of tertiary amines.
作者信息
Wagner Alexander, Ofial Armin R
机构信息
Department Chemie der Ludwig-Maximilians-Universität München , Butenandtstrasse 5-13 (Haus F), 81377 München, Germany.
出版信息
J Org Chem. 2015 Mar 6;80(5):2848-54. doi: 10.1021/jo502846c. Epub 2015 Feb 11.
PMID:25625439
Abstract
Oxidation at the sulfur of the safe-to-handle potassium thiocyanate releases cyanide units that are trapped in the presence of co-oxidized tertiary amines to form α-amino nitriles. These cyanations work in aqueous solutions and do not require a catalyst, nor do they form toxic byproducts.
摘要
易于处理的硫氰酸钾中的硫发生氧化，释放出氰化物单元，这些氰化物单元在共氧化的叔胺存在下被捕获，形成α-氨基腈。这些氰化反应在水溶液中进行，不需要催化剂，也不会形成有毒副产物。
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