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非洲猪瘟病毒基因型和血清群的比较分析

Comparative analysis of African swine fever virus genotypes and serogroups.

作者信息

Malogolovkin Alexander, Burmakina Galina, Titov Ilya, Sereda Alexey, Gogin Andrey, Baryshnikova Elena, Kolbasov Denis

出版信息

Emerg Infect Dis. 2015 Feb;21(2):312-5. doi: 10.3201/eid2102.140649.

DOI:10.3201/eid2102.140649
PMID:25625574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4313636/
Abstract

African swine fever virus (ASFV) causes highly lethal hemorrhagic disease among pigs, and ASFV's extreme antigenic diversity hinders vaccine development. We show that p72 ASFV phylogenetic analysis does not accurately define ASFV hemadsorption inhibition assay serogroups. Thus, conventional ASFV genotyping cannot discriminate between viruses of different virulence or predict efficacy of a specific ASFV vaccine.

摘要

非洲猪瘟病毒（ASFV）在猪群中引发高致死性出血性疾病，且ASFV的极端抗原多样性阻碍了疫苗研发。我们发现，p72 ASFV系统发育分析无法准确界定ASFV血细胞吸附抑制试验血清群。因此，传统的ASFV基因分型无法区分不同毒力的病毒，也无法预测特定ASFV疫苗的效力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ed/4313636/7afb078bc1ed/14-0649-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ed/4313636/2ff778b72998/14-0649-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ed/4313636/7afb078bc1ed/14-0649-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ed/4313636/2ff778b72998/14-0649-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ed/4313636/7afb078bc1ed/14-0649-F2.jpg

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