Simon Daniel, Nicol Josi Mara Botome, Sabino da Silva Sabrina, Graziottin Camila, Silveira Patrícia Corso, Ikuta Nilo, Regner Andrea
Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde .
Brain Inj. 2015;29(5):612-7. doi: 10.3109/02699052.2014.995228. Epub 2015 Jan 27.
Severe traumatic brain injury (TBI) is associated with a 30-70% mortality rate. Nevertheless, in clinical practice there are no effective biomarkers for the prediction of fatal outcome following severe TBI. Therefore, the aim was to determine whether ferritin serum levels are associated with ICU mortality in patients with severe TBI.
This prospective study enrolled 69 male patients who suffered severe TBI [Glasgow Coma Scale (GCS) 3-8 at emergency room admission]. The serum ferritin protein level was determined at ICU admission (mean 5.6 ± 2.5 hours after emergency room admission).
Severe TBI was associated with a 39% mortality rate. Higher serum ferritin concentrations were significantly associated with lower hospital admission GCS scores (p = 0.049). Further, there was a significant association between higher ferritin concentrations and fatal outcome (289.5 ± 27.1 µg L(-1) for survivors and 376.5 ± 31.5 µg L(-1) for non-survivors, respectively, mean ± SEM, p = 0.032).
Increased serum ferritin levels were associated with lower hospital admission GCS scores and predicted short-term fatal outcome following severe TBI.
重度创伤性脑损伤（TBI）的死亡率为30%-70%。然而，在临床实践中，尚无有效的生物标志物可用于预测重度TBI后的致命结局。因此，本研究旨在确定血清铁蛋白水平是否与重度TBI患者的重症监护病房（ICU）死亡率相关。
本前瞻性研究纳入了69例男性重度TBI患者[急诊入院时格拉斯哥昏迷量表（GCS）评分为3-8分]。在ICU入院时测定血清铁蛋白水平（急诊入院后平均5.6±2.5小时）。
重度TBI的死亡率为39%。较高的血清铁蛋白浓度与较低的入院时GCS评分显著相关（p=0.049）。此外，较高的铁蛋白浓度与致命结局之间存在显著关联（幸存者为289.5±27.1μg/L，非幸存者为376.5±31.5μg/L，均值±标准误，p=0.032）。
血清铁蛋白水平升高与较低的入院时GCS评分相关，并可预测重度TBI后的短期致命结局。
