巴西低流行地区居民过敏反应与曼氏血吸虫感染之间的关联
Association between allergic responses and Schistosoma mansoni infection in residents in a low-endemic setting in Brazil.
作者信息
Oliveira Sara Menezes de, Bezerra Fernando Schemelzer de Moraes, Carneiro Teiliane Rodrigues, Pinheiro Marta Cristhiany Cunha, Queiroz José Ajax Nogueira
机构信息
Departamento de Patologia e Medicina Legal, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
出版信息
Rev Soc Bras Med Trop. 2014 Nov-Dec;47(6):770-4. doi: 10.1590/0037-8682-0249-2014.
INTRODUCTION
Schistosomiasis is endemic in 76 countries and territories. Several studies have found an inverse correlation between parasitic disease and the development of allergies. The purpose of the present study was to determine whether infection with Schistosoma mansoni in subjects with a low parasite load is protective against allergy. The final sample consisted of 39 S. mansoni-positive and 52 S. mansoni-negative residents of a small community in northeastern Brazil.
METHODS
All subjects were submitted to the Kato-Katz test, anti-S. mansoni IgG measurement, the prick test for aeroallergens, eosinophil counts and serum IgE measurement.
RESULTS
Subjects who reacted to one or more antigens in the prick test were considered allergic. Only 7 S. mansoni-positive subjects (17.9%) reacted to one or more antigens, whereas 20 S. mansoni-negative subjects (38.5%) tested positive for allergy.
CONCLUSIONS
Our findings suggest that, in areas of low endemicity, infection with S. mansoni significantly reduces the risk of the development of allergy in subjects with a low parasite load.
引言
血吸虫病在76个国家和地区呈地方性流行。多项研究发现寄生虫病与过敏症的发展之间存在负相关。本研究的目的是确定低寄生虫负荷的曼氏血吸虫感染是否对过敏具有保护作用。最终样本包括巴西东北部一个小社区的39名曼氏血吸虫阳性居民和52名曼氏血吸虫阴性居民。
方法
所有受试者均接受了加藤厚涂片法检测、抗曼氏血吸虫IgG测量、气传变应原点刺试验、嗜酸性粒细胞计数和血清IgE测量。
结果
点刺试验中对一种或多种抗原产生反应的受试者被视为过敏。只有7名曼氏血吸虫阳性受试者（17.9%）对一种或多种抗原产生反应，而20名曼氏血吸虫阴性受试者（38.5%）过敏检测呈阳性。
结论
我们的研究结果表明，在低度流行地区，曼氏血吸虫感染显著降低了低寄生虫负荷受试者发生过敏的风险。
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