Center for RNA Research, Institute for Basic Science, Department of Chemistry, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 151-747, South Korea.
Department of Chemistry, Chung-Ang University, Seoul, 156-756, South Korea.
Small. 2015 Jun 3;11(21):2527-35. doi: 10.1002/smll.201402269. Epub 2015 Jan 27.
The paper reports a facile one-pot synthesis of core@shell nanoparticles (NPs) composed of Au core and graphene oxide nanocolloid (GON) shell. Unique properties of Au NPs and GON can be incorporated into a single nanohybrid structure to provide desirable functions for theranosis such as localized surface plasmon resonance, Raman scattering, amphiphilic surface, and photothermal conversion. Synthesis of Au@GON NPs is achieved by simple one-pot reaction in aqueous phase utilizing GON as a reducing and stabilizing agent without any additional reducing agent. The zinc phthalocyanine, a photosensitizer, loaded Au@GON NPs show excellent multifunctional properties for combinational treatment of photothermal and photodynamic therapy in addition to Raman bioimaging with low cytotoxicity.
本文报道了一种简便的一锅法合成核壳纳米粒子（NPs）的方法，该纳米粒子由 Au 核和氧化石墨烯纳米胶体（GON）壳组成。Au NPs 和 GON 的独特性质可以被整合到单个纳米杂化结构中，为治疗提供理想的功能，如局部表面等离子体共振、拉曼散射、两亲表面和光热转换。Au@GON NPs 的合成是通过在水相中简单的一锅反应实现的，利用 GON 作为还原剂和稳定剂，无需任何额外的还原剂。锌酞菁作为一种光敏剂，负载在 Au@GON NPs 上，除了具有低细胞毒性的拉曼生物成像外，还表现出优异的光热和光动力治疗的多功能特性。
