[Toxic-dynamics of lead compound and zinc compound in the evaluation of experimental animal behavior].

The aim of the studies was to determine the effect of lead and zinc compound on the mice behaviour. The animals were given intraperitoneally the solution of lead acetate and zinc chloride for 30 days. The mice were subjected to the tests determining their effects on the coordination of movements, the spontaneous motility, the cognitive motility and the motility in the straight rod test as well as on the body temperature. Due to the prolonged exposition to the action of lead and zinc compounds the inhibiting effect of those substances in the central nervous system in the maximal doses was proved while in the minimal doses the antagonistic action of zinc compound was observed. The nerve conduction disorders in the peripheral and central nervous system after the administration of the maximal doses of lead compound may be due to the inhibiting effect of this compound while the lack of this effect in the minimal doses probably results from the antagonistic action of zinc compound.