Moreno Abadía V, Bermúdez García J M, Maldonado Martín A, Rico Irles J
An Med Interna. 1989 Sep;6(9):466-71.
DIC in patients affected by cirrhosis, accompanied by portal hypertension and splenomegaly, has been suspected in the past. The main aim of this study is to ascertain the incidence of this phenomenon. We carried out coagulation and fibrinolytic tests in 113 cirrhotic patients and 20 healthy control persons. We found chronic consumption coagulopathy at analysis level in 28 cases (24.8%) with a decrease of fibrinogen, factor V, kallikrein, platelets, prothrombin complex activity, increase of PDF, partial thromboplastic time and euglobulin lysis. 25 cases had active cirrhosis, with ascites, variceal bleeding and/or hepatic encephalopathy; 3 were non-active cirrhosis. Only 7 patients had clinical DIC. We observed that coagulation disorders increased with more active cirrhosis.
肝硬化患者伴有门静脉高压和脾肿大，过去曾怀疑存在弥散性血管内凝血（DIC）。本研究的主要目的是确定这种现象的发生率。我们对113例肝硬化患者和20名健康对照者进行了凝血和纤溶试验。我们发现，在分析水平上，28例（24.8%）存在慢性消耗性凝血病，表现为纤维蛋白原、因子V、激肽释放酶、血小板、凝血酶原复合物活性降低，PDF、部分凝血活酶时间和优球蛋白溶解增加。25例为活动性肝硬化，伴有腹水、静脉曲张出血和/或肝性脑病；3例为非活动性肝硬化。只有7例患者有临床DIC。我们观察到，随着肝硬化活动性增加，凝血障碍也会加重。
