Department of Pediatric Pulmonology and Pediatric Allergy, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
University of Groningen, University Medical Centre Groningen, GRIAC Research Institute, Groningen, the Netherlands.
Allergy. 2015 Jun;70(6):616-24. doi: 10.1111/all.12582. Epub 2015 Mar 26.
Although food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may contribute to HRQL in food-allergic patients. Therefore, the aim of this study was to identify factors which may predict HRQL of food-allergic patients and also to investigate the specific impact of having experienced anaphylaxis and being prescribed an EAI on HRQL.
A total of 648 European food-allergic patients (404 adults, 244 children) completed an age-specific questionnaire package including descriptive questions. Multivariable regression analyses were performed to develop models for predicting HRQL of these patients.
For adults, the prediction model accounted for 62% of the variance in HRQL and included perceived disease severity, type of symptoms, having a fish or milk allergy, and gender. For children, the prediction model accounted for 28% of the variance in HRQL and included perceived disease severity, having a peanut or soy allergy, and country of origin. For both adults and children, neither experiencing anaphylaxis nor being prescribed an epinephrine auto-injector (EAI) contributed to impairment of HRQL.
In this study, food allergy-related HRQL may be predicted to a greater extent in adults than in children. Allergy to certain foods may cause greater HRQL impairment than others. Country of origin may affect HRQL, at least in children. Experiencing anaphylaxis or being prescribed an EAI has no impact on HRQL in either adults or children.
尽管食物过敏普遍被认为会降低健康相关生活质量（HRQL），但研究发现，即使在考虑到感知疾病严重程度的差异后，不同国家的 HRQL 也存在显著差异。然而，除了疾病严重程度之外，还有哪些因素可能会影响食物过敏患者的 HRQL，这方面的了解甚少。因此，本研究旨在确定可能预测食物过敏患者 HRQL 的因素，并探讨经历过敏反应和处方 EAI 对 HRQL 的具体影响。
共有 648 名欧洲食物过敏患者（404 名成人，244 名儿童）完成了一份特定年龄段的问卷包，其中包括描述性问题。进行多变量回归分析以建立预测这些患者 HRQL 的模型。
对于成年人，预测模型解释了 HRQL 方差的 62%，包括感知疾病严重程度、症状类型、患有鱼类或牛奶过敏以及性别。对于儿童，预测模型解释了 HRQL 方差的 28%，包括感知疾病严重程度、患有花生或大豆过敏以及原籍国。对于成年人和儿童，经历过敏反应或处方肾上腺素自动注射器（EAI）都不会导致 HRQL 受损。
在这项研究中，与食物过敏相关的 HRQL 在成年人中的预测程度大于儿童。对某些食物的过敏可能比其他食物更会导致 HRQL 受损。原籍国可能至少会影响儿童的 HRQL。经历过敏反应或处方 EAI 对成人或儿童的 HRQL 均无影响。
