Stensgaard A, Bindslev-Jensen C, Nielsen D, Munch M, DunnGalvin A
Odense Research Center for Anaphylaxis (ORCA), Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark.
Migrant Health Clinic, Odense University Hospital, Odense, Denmark.
Clin Exp Allergy. 2017 Apr;47(4):530-539. doi: 10.1111/cea.12849. Epub 2016 Dec 14.
Studies of children with food allergy typically only include the mother and have not investigated the relationship between the amount of allergen needed to elicit a clinical reaction (threshold) and health-related quality of life (HRQL). Our aims were (i) to compare self-reported and parent-reported HRQL in different age groups, (ii) to evaluate the impact of severity of allergic reaction and threshold on HRQL, and (iii) to investigate factors associated with patient-reported and parent-reported HRQL.
Age-appropriate Food Allergy Quality of Life Questionnaires (FAQLQ) were completed by 73 children, 49 adolescents and 29 adults with peanut, hazelnut or egg allergy. Parents (197 mothers, 120 fathers) assessed their child's HRQL using the FAQLQ-Parent form. Clinical data and threshold values were obtained from a hospital database. Significant factors for HRQL were investigated using univariate and multivariate regression.
Female patients reported greater impact of food allergy on HRQL than males did. Egg and hazelnut thresholds did not affect HRQL, but lower peanut threshold was associated with worse HRQL. Both parents scored their child's HRQL better than the child's own assessment, but whereas mother-reported HRQL was significantly affected by limitations in the child's social life, father-reported HRQL was affected by limitations in the family's social life. Severity of allergic reaction did not contribute significantly to HRQL.
The risk of accidental allergen ingestion and limitations in social life are associated with worse HRQL. Fathers provide a unique perspective and should have a greater opportunity to contribute to food allergy research.
对食物过敏儿童的研究通常仅纳入母亲，尚未探究引发临床反应所需的过敏原量（阈值）与健康相关生活质量（HRQL）之间的关系。我们的目的是：（i）比较不同年龄组自我报告和家长报告的HRQL；（ii）评估过敏反应严重程度和阈值对HRQL的影响；（iii）调查与患者报告和家长报告的HRQL相关的因素。
73名儿童、49名青少年和29名对花生、榛子或鸡蛋过敏的成人完成了适合其年龄的食物过敏生活质量问卷（FAQLQ）。家长（197名母亲、120名父亲）使用FAQLQ-家长版评估其孩子的HRQL。临床数据和阈值来自医院数据库。使用单变量和多变量回归研究HRQL的显著因素。
女性患者报告食物过敏对HRQL的影响大于男性。鸡蛋和榛子阈值不影响HRQL，但较低的花生阈值与较差的HRQL相关。家长对孩子HRQL的评分均高于孩子自己的评估，但母亲报告的HRQL受孩子社交生活受限的显著影响，而父亲报告的HRQL受家庭社交生活受限的影响。过敏反应的严重程度对HRQL没有显著影响。
意外摄入过敏原的风险和社交生活受限与较差的HRQL相关。父亲提供了独特的视角，应有更多机会参与食物过敏研究。
