Department of Paediatrics, Division of Paediatric Pulmonology and Paediatric Allergy, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Allergy. 2010 Aug;65(8):1031-8. doi: 10.1111/j.1398-9995.2009.02304.x. Epub 2010 Feb 1.
Health-related quality of life (HRQL) has never been measured with both generic and disease-specific questionnaires in the same group of food allergic patients. The aim of this study was to compare HRQL of food allergic patients as measured with generic and disease-specific questionnaires.
Generic questionnaires (CHQ-CF87 and RAND-36) and disease-specific HRQL questionnaires (FAQLQ-CF, -TF and -AF) were completed by 79 children, 74 adolescents and 72 adults with food allergy. Floor and ceiling effects, percentage of agreement and multivariate stepwise regression analysis were used to compare the generic and disease-specific measurements.
The Food Allergy Quality of Life Questionnaires (FAQLQs) showed minimal floor or ceiling effects. The CHQ-CF87 and RAND-36 showed minimal floor effects, but remarkable ceiling effects (> 73%) were found for the scales role functioning-emotional (RE), role functioning-behaviour (RB), role functioning-physical (RP) in children and adolescents and the scale RE (> 79%) in adults. Additionally, we found low percentages of agreement between the generic and disease-specific questionnaires to identify the same food allergic patients with the best or worst HRQL. Only patients with the best disease-specific HRQL also tended to have the best generic HRQL. Finally, the explained variance in HRQL by patient characteristics was higher in the disease-specific questionnaires (30.7-62.8%) than in the generic scales (6.7-31.7%).
Disease-specific HRQL questionnaires may be more suitable to measure clinically important impairments in HRQL or HRQL differences over time in food allergic patients. However, generic HRQL questionnaires are indispensable for the comparison between different diseases and are thus complementary.
在同一批食物过敏患者中，从未同时使用通用和疾病特异性问卷来测量与健康相关的生活质量（HRQL）。本研究的目的是比较使用通用和疾病特异性问卷测量的食物过敏患者的 HRQL。
79 名儿童、74 名青少年和 72 名成年人用通用问卷（CHQ-CF87 和 RAND-36）和疾病特异性 HRQL 问卷（FAQLQ-CF、-TF 和 -AF）完成了问卷调查。使用地板和天花板效应、一致性百分比和多元逐步回归分析来比较通用和疾病特异性测量。
食物过敏生活质量问卷（FAQLQs）显示出最小的地板或天花板效应。CHQ-CF87 和 RAND-36 显示出最小的地板效应，但在儿童和青少年的角色功能-情感（RE）、角色功能-行为（RB）、角色功能-身体（RP）和成年人的 RE 量表（>79%）中观察到显著的天花板效应（>73%）。此外，我们发现通用和疾病特异性问卷之间识别具有最佳或最差 HRQL 的相同食物过敏患者的一致性百分比较低。只有具有最佳疾病特异性 HRQL 的患者也倾向于具有最佳的通用 HRQL。最后，疾病特异性问卷中患者特征对 HRQL 的解释方差（30.7%-62.8%）高于通用量表（6.7%-31.7%）。
疾病特异性 HRQL 问卷可能更适合测量食物过敏患者 HRQL 中的临床重要障碍或随时间变化的 HRQL 差异。然而，通用 HRQL 问卷对于不同疾病之间的比较是不可或缺的，因此是互补的。
