Abarbanel Mental Health Centre, Bat Yam, Israel.
Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Acta Psychiatr Scand. 2015 Oct;132(4):301-5. doi: 10.1111/acps.12396. Epub 2015 Jan 28.
Schizophrenic patients have an increased risk for obesity compared with the general population. Evidence suggests the existence of an inflammatory process in the etiology of both obesity and schizophrenia. Our study compares in vitro secretion of inflammatory cytokines by peripheral blood mononuclear cells (PBMC) obtained from obese and non-obese schizophrenic patients.
Mononuclear cells were isolated from 20 obese (BMI >27) and 20 non-obese (BMI <24) schizophrenic in-patients. The levels of TNF-α, IL-1β, IL-6, IL-1ra, IL-10 or IL-2 and IFN-γ in the supernatants of stimulated PBMC, as well as leptin and adiponectin serum values were evaluated.
Peripheral blood mononuclear cells from patients in the obese group showed a significantly increased TNF-α and IL-1β production, whereas the release of IL-1ra was decreased as compared with the non-obese group. In the obese group, the serum concentration of leptin was significantly higher and that of adiponectin was significantly lower. The results of the remaining cytokines did not differ between the two groups.
Our study indicates the existence of a difference between obese and non-obese schizophrenic subjects as for inflammatory cytokine production and serum leptin and adiponectin levels, suggesting a 'subclinical inflammatory state' in obese schizophrenic patients that may contribute to a predisposition to inflammation and infections.
与普通人群相比，精神分裂症患者肥胖的风险增加。有证据表明，肥胖和精神分裂症的病因中都存在炎症过程。我们的研究比较了肥胖和非肥胖精神分裂症患者外周血单个核细胞（PBMC）体外分泌的炎症细胞因子。
从 20 名肥胖（BMI＞27）和 20 名非肥胖（BMI＜24）精神分裂症住院患者中分离出单核细胞。评估刺激 PBMC 上清液中 TNF-α、IL-1β、IL-6、IL-1ra、IL-10 或 IL-2 和 IFN-γ的水平以及血清瘦素和脂联素的浓度。
与非肥胖组相比，肥胖组患者的外周血单个核细胞 TNF-α 和 IL-1β 的产生明显增加，而 IL-1ra 的释放则减少。在肥胖组，血清瘦素浓度明显升高，脂联素浓度明显降低。两组之间其余细胞因子的结果没有差异。
我们的研究表明，肥胖和非肥胖精神分裂症患者在炎症细胞因子产生和血清瘦素和脂联素水平方面存在差异，提示肥胖精神分裂症患者存在“亚临床炎症状态”，可能导致炎症和感染易感性增加。
