Zhou Yong, Wang Dandan, Yang Xin, Wang Anxin, Gao Xiang, Guo Yuming, Wu Shouling, Zhao Xingquan
1] Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2] China National Clinical Research Center for Neurological Diseases, Beijing, China [3] Center of Stroke, Beijing Institute for Brain Disorders [4] Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease.
Department of General Practice, School of General Practice and Continuing Education, Capital Medical University, Beijing, China.
Sci Rep. 2015 Jan 28;5:8076. doi: 10.1038/srep08076.
Menopause is an important physiological stage in women's life. The potential association of menopause with carotid intima-media thickness as well as with occurrence and stability of carotid plaque in Chinese female population is unclear. We conducted a population-based, cross-sectional study by recruiting 2,131 participants aged above 40 years from northeast of China. Carotid intima-media thickness (CIMT), presence of carotid plaque and its stability were evaluated by carotid duplex sonography. Among the participants, 1,133 (53.2%) were identified to be postmenopausal. After adjusting for potential confounding factors, presence of CIMT at 50(th-) 75(th) and ≥75(th) percentiles, carotid plaque and its unstable status were found to be significantly associated with the postmenopausal status (P < 0.001). When matched the participants by age, post-menopausal status was still associated with a higher risk of having unstable plaque. Moreover, our data show that postmenopausal status is a risk factor for intracranial arterial stenosis when compared with premenopausal status in the univariate analysis (OR = 1.314, P = 0.043), and such relationship is lost when the confounding factors are adjusted (OR = 0.828, P = 0.225). In conclusion, the vascular risk factors increase as the menopausal status changes. Compared with premenopausal status, postmenopausal status is associated with higher morbidity of CIMT, carotid plaque and its unstable status.
绝经是女性生命中的一个重要生理阶段。在中国女性人群中，绝经与颈动脉内膜中层厚度以及颈动脉斑块的发生和稳定性之间的潜在关联尚不清楚。我们进行了一项基于人群的横断面研究，从中国东北地区招募了2131名40岁以上的参与者。通过颈动脉双功超声评估颈动脉内膜中层厚度（CIMT）、颈动脉斑块的存在及其稳定性。在参与者中，1133名（53.2%）被确定为绝经后。在调整潜在混杂因素后，发现第50至75百分位数和≥75百分位数处的CIMT、颈动脉斑块及其不稳定状态与绝经后状态显著相关（P<0.001）。当按年龄匹配参与者时，绝经后状态仍与不稳定斑块的较高风险相关。此外，我们的数据显示，在单因素分析中，与绝经前状态相比，绝经后状态是颅内动脉狭窄的一个危险因素（OR=1.314，P=0.043），而在调整混杂因素后这种关系消失（OR=0.828，P=0.225）。总之，血管危险因素随着绝经状态的变化而增加。与绝经前状态相比，绝经后状态与CIMT、颈动脉斑块及其不稳定状态的更高发病率相关。
