Luo Yuqi, Ma Xiaojing, Hao Yaping, Xiong Qin, Xu Yiting, Pan Xiaoping, Bao Yuqian, Jia Weiping
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, 600 Yishan Road, Shanghai, 200233, China.
Cardiovasc Diabetol. 2015 Jun 16;14:82. doi: 10.1186/s12933-015-0245-9.
The relationship between osteocalcin and atherosclerosis remains unclear. This might be due to different degrees of confounding from factors that are associated with serum osteocalcin level, such as metabolic-related variables. This study aimed to investigate the relationship between serum osteocalcin level and carotid intima-media thickness (C-IMT) in a metabolically healthy population.
A total of 476 subjects with normal values for weight, glucose tolerance, blood pressure, and lipids (age range, 20-75 years; 155 men, 201 premenopausal women, 120 postmenopausal women) from the Shanghai Obesity Study were recruited for this cross-sectional study. Subjects with a history of cardiovascular disease or carotid plaque were excluded. C-IMT was measured by ultrasonography. Serum osteocalcin level was assessed by an electrochemiluminescence immunoassay.
Median C-IMT in the entire study population was 0.55 mm with an interquartile range of 0.50-0.60 mm. C-IMT in premenopausal women was significantly lower than that in men and postmenopausal women (all P < 0.001). The median (interquartile range) of serum osteocalcin level in the entire population was 17.02 (13.31-21.47) ng/mL. Serum osteocalcin level in postmenopausal women was significantly higher than that in men and premenopausal women (all P < 0.001), while the level of serum osteocalcin in men was also significantly higher than that in premenopausal women (P < 0.001). No significant correlation was found between C-IMT and serum osteocalcin level in either men or postmenopausal women. There was a significant, inverse correlations between C-IMT and serum osteocalcin level in premenopausal women after adjustment of age, but this association was eliminated after adjustment for other confounding factors.
Serum osteocalcin level was not independently associated with C-IMT in a metabolically healthy Chinese population.
骨钙素与动脉粥样硬化之间的关系仍不明确。这可能是由于与血清骨钙素水平相关的因素（如代谢相关变量）存在不同程度的混杂作用。本研究旨在调查代谢健康人群中血清骨钙素水平与颈动脉内膜中层厚度（C-IMT）之间的关系。
从上海肥胖研究中招募了476名体重、糖耐量、血压和血脂正常的受试者（年龄范围20 - 75岁；男性155名，绝经前女性201名，绝经后女性120名）进行这项横断面研究。排除有心血管疾病或颈动脉斑块病史的受试者。通过超声测量C-IMT。采用电化学发光免疫分析法评估血清骨钙素水平。
整个研究人群的C-IMT中位数为0.55 mm，四分位间距为0.50 - 0.60 mm。绝经前女性的C-IMT显著低于男性和绝经后女性（所有P < 0.001）。整个人群血清骨钙素水平的中位数（四分位间距）为17.02（13.31 - 21.47）ng/mL。绝经后女性的血清骨钙素水平显著高于男性和绝经前女性（所有P < 0.001），而男性的血清骨钙素水平也显著高于绝经前女性（P < 0.001）。在男性或绝经后女性中，未发现C-IMT与血清骨钙素水平之间存在显著相关性。在调整年龄后，绝经前女性的C-IMT与血清骨钙素水平之间存在显著的负相关，但在调整其他混杂因素后，这种关联消失。
在代谢健康的中国人群中，血清骨钙素水平与C-IMT无独立相关性。
