Li Zheng, Yu Xin, Shen Jianxiong
Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College, 100730, Beijing, China.
Environ Sci Pollut Res Int. 2015 Apr;22(8):5751-5. doi: 10.1007/s11356-015-4144-0. Epub 2015 Jan 29.
Growing evidence has proved that many aspects of our lifestyle and the environment contribute to the development of congenital disease. Congenital spinal deformities are due to anomalous development of the vertebrae including failure of formation and segmentation during embryogenesis. The causes of congenital scoliosis have not been fully identified. A variety of factors are implicated in the development of vertebral abnormalities. Previous studies have demonstrated that both genetics and environmental factors are implicated in the development of vertebral abnormalities. However, no specific cause for congenital scoliosis has been identified. In our review, we focus on the environmental factors for the development of congenital scoliosis. Various maternal exposures during pregnancy including hypoxia, alcohol use, vitamin deficiency, valproic acid, boric acid, and hyperthermia have been observed to be associated with the occurrence of congenital scoliosis. This review describes the major environmental contributors of congenital scoliosis with an emphasis on treatment aspects associated with environmental disposition in congenital scoliosis.
越来越多的证据表明，我们生活方式和环境的许多方面都与先天性疾病的发生有关。先天性脊柱畸形是由于椎体发育异常，包括胚胎发育过程中形成和分节失败。先天性脊柱侧凸的病因尚未完全明确。多种因素与椎体异常的发生有关。先前的研究表明，遗传因素和环境因素都与椎体异常的发生有关。然而，尚未确定先天性脊柱侧凸的具体病因。在我们的综述中，我们关注先天性脊柱侧凸发生的环境因素。已观察到孕期母亲的各种暴露，包括缺氧、饮酒、维生素缺乏、丙戊酸、硼酸和体温过高，都与先天性脊柱侧凸的发生有关。本综述描述了先天性脊柱侧凸的主要环境因素，并重点介绍了与先天性脊柱侧凸环境易感性相关的治疗方面。
