Kitada S, Wein A J, Kato K, Levin R M
Division of Urology, University of Pennsylvania School of Medicine, Philadelphia.
J Urol. 1989 Jan;141(1):166-9. doi: 10.1016/s0022-5347(17)40633-1.
Studies on the effect of partial bladder outlet obstruction demonstrate that significant alterations in urinary bladder structure and function occur within 24 hours of the creation of the obstruction. These studies suggest that many of the functional and structural alterations following partial outlet obstruction may result from the initial overdistension which occurs within the first 24 hours. In these present studies, we investigated the time course of the effect of complete obstruction of the rabbit urinary bladder on the contractile response to bethanechol and field stimulation and on the muscarinic receptor density. Male White New Zealand rabbits were divided into five groups: controls, four, eight, 20, and 24 hours of complete obstruction. The results demonstrated that there was a significant decrease in both the contractile response to muscarinic stimulation and muscarinic receptor density at four hours following outlet obstruction (at a time when there was no bladder overdistension). The receptor density and contractile response to stimulation further decreased over the 24 hour period. These studies indicate that the initial decrease in muscarinic receptor density and contractile response to muscarinic stimulation may be mediated in part by the high level of spontaneous contractile activity induced by ligation of the urethra.
关于部分膀胱出口梗阻影响的研究表明，在梗阻形成后的24小时内，膀胱的结构和功能会发生显著改变。这些研究提示，部分出口梗阻后许多功能和结构改变可能源于最初24小时内发生的过度扩张。在本研究中，我们调查了兔膀胱完全梗阻对乙酰甲胆碱收缩反应、场刺激收缩反应以及毒蕈碱受体密度影响的时间进程。雄性新西兰白兔被分为五组：对照组、梗阻4小时、8小时、20小时和24小时组。结果显示，在出口梗阻4小时后（此时膀胱无过度扩张），对毒蕈碱刺激的收缩反应和毒蕈碱受体密度均显著降低。在24小时期间，受体密度和对刺激的收缩反应进一步降低。这些研究表明，毒蕈碱受体密度的最初降低以及对毒蕈碱刺激的收缩反应可能部分是由尿道结扎诱导的高水平自发收缩活动介导的。
