• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds.

作者信息

Walsh D A, Franzyshen S K, Yanni J M

机构信息

Department of Chemical Research and Pharmacology, A.H. Robins Company, Richmond, Virginia 23261-6609.

出版信息

J Med Chem. 1989 Jan;32(1):105-18. doi: 10.1021/jm00121a022.

DOI:10.1021/jm00121a022
PMID:2562852
Abstract

A series of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines was synthesized and evaluated for antiallergy activity. Several analogues had potent activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity. In particular 1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl] propoxy]-3-methoxyphenyl]ethanone (1, AHR-5333) was more potent than oxatomide and terfenadine in this assay.

摘要

相似文献

1
Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds.
J Med Chem. 1989 Jan;32(1):105-18. doi: 10.1021/jm00121a022.
2
Piperidineacrylate derivatives as potential antiallergy agents.
Chem Pharm Bull (Tokyo). 1993 May;41(5):882-8. doi: 10.1248/cpb.41.882.
3
The synthesis and antiallergy activity of 1-(aryloxy)-4-(4-arylpiperazinyl)-2-butanol derivatives.
J Med Chem. 1990 Jun;33(6):1823-7. doi: 10.1021/jm00168a044.
4
Effects of AHR-5333, a new potential antiallergy compound, in in vivo models of immediate hypersensitivity.
Int Arch Allergy Appl Immunol. 1988;85(4):428-33. doi: 10.1159/000234546.
5
Synthesis, calcium-channel-blocking activity, and antihypertensive activity of 4-(diarylmethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds.4-（二芳基甲基）-1-[3-（芳氧基）丙基]哌啶及其结构相关化合物的合成、钙通道阻滞活性和抗高血压活性
J Med Chem. 1991 Oct;34(10):3011-22. doi: 10.1021/jm00114a009.
6
Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acryl amides.
J Med Chem. 1989 Mar;32(3):583-93. doi: 10.1021/jm00123a012.
7
4-(Indolyl-3)-1-(benzimidazolonylalkyl)-piperidines, a novel group of potential antiallergy compounds.
Arzneimittelforschung. 1985;35(1A):272-6. doi: 10.1002/chin.198528212.
8
Acrylamide derivatives as antiallergic agents. III. Synthesis and structure-activity relationships of N-[4-(4-diphenylmethyl-1-piperazinyl)butyl]- and N-[4-(4-diphenylmethylene-1-piperidyl)butyl]-3-heteroarylacry lamides.
Chem Pharm Bull (Tokyo). 1989 Mar;37(3):684-7. doi: 10.1248/cpb.37.684.
9
Studies on antiallergy agents. III. Synthesis of 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylic acids and related compounds.
Chem Pharm Bull (Tokyo). 1989 Jul;37(7):1780-7. doi: 10.1248/cpb.37.1780.
10
Synthesis and antiallergic activity of N-[4-(4-diphenylmethyl-1-piperazinyl)butyl]-1,4-dihydro-4-oxopyridine-3 - carboxamides.
Chem Pharm Bull (Tokyo). 1989 May;37(5):1256-9. doi: 10.1248/cpb.37.1256.

引用本文的文献

1
Ionic liquid-supported synthesis of piperazine derivatives as potential insecticides.离子液体支持的哌嗪衍生物的合成及其作为潜在杀虫剂的应用。
Mol Divers. 2014 Feb;18(1):195-202. doi: 10.1007/s11030-013-9492-4. Epub 2013 Nov 27.
2
Enantioselective intramolecular openings of oxetanes catalyzed by (salen)Co(III) complexes: access to enantioenriched tetrahydrofurans.（手性水杨醛亚胺）钴（III）配合物催化的环氧乙烷的对映选择性分子内开环反应：获得对映体富集的四氢呋喃。
J Am Chem Soc. 2009 Mar 4;131(8):2786-7. doi: 10.1021/ja809176m.
3
The in vivo and in vitro activity of AHR-13268D, a new antiallergic/antihistaminic agent.
Agents Actions. 1990 Nov;31(3-4):210-8. doi: 10.1007/BF01997610.