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微小RNA-608基因多态性对癌症易感性和生存率的影响：一项荟萃分析

The role of microRNA-608 polymorphism on the susceptibility and survival of cancer: a meta-analysis.

作者信息

Dai Zhi-Ming, Lv Jian-Rui, Liu Kang, Lei Xiao-Ming, Li Wei, Wu Gang, Liu Xing-Han, Zhu Yu-Xiao, Hao Qian, Dai Zhi-Jun

机构信息

Department of Anesthesiology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.

Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.

出版信息

Aging (Albany NY). 2018 Jun 16;10(6):1402-1414. doi: 10.18632/aging.101476.

DOI:10.18632/aging.101476
PMID:29909406
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6046227/
Abstract

The role of rs4919510 polymorphism in microRNA-608 (miR-608) and cancer susceptibility and prognosis remain controversial and debatable. We conducted a meta-analysis of twenty-four eligible publications on the association of rs4919510 polymorphism with cancer risk and/or prognosis. Odds ratios, hazard ratios, and 95% confidence interval were used to investigate the association between this polymorphism and susceptibility, overall survival, and recurrence-free survival of cancer. Overall, eighteen case-control studies and nine cohort studies evaluated the susceptibility and prognostic value of rs4919510 polymorphism in cancer, respectively. Pooled analysis showed that rs4919510 polymorphism was not associated with cancer risk in all five genetic models. When stratifying by different cancer sites, rs4919510 polymorphism was detected to have a significant association with a decreased risk of colorectal cancer in homozygous model ( = 0.006) and recessive model ( = 0.001), subgroup analysis also emerged a weakened correlation between rs4919510 polymorphism and an increased risk of papillary thyroid cancer in heterozygote model ( = 0.04). Furthermore, the prognosis of rs4919510 variant in cancer patients showed that rs4919510 GG genotype was significant association with poor recurrence-free survival in homozygous models ( = 0.04). The meta-analysis suggested that the microRNA-608 rs4919510 polymorphism maybe associate with a significantly decreased risk for colorectal cancer. Further investigations on larger populations are required to evaluate and confirm this relationship.

摘要

rs4919510多态性在微小RNA - 608（miR - 608）与癌症易感性及预后中的作用仍存在争议。我们对24篇关于rs4919510多态性与癌症风险和/或预后关联的合格出版物进行了荟萃分析。采用优势比、风险比和95%置信区间来研究这种多态性与癌症易感性、总生存期和无复发生存期之间的关联。总体而言，分别有18项病例对照研究和9项队列研究评估了rs4919510多态性在癌症中的易感性和预后价值。汇总分析表明，在所有五种遗传模型中，rs4919510多态性与癌症风险均无关联。按不同癌症部位分层时，在纯合子模型（ = 0.006）和隐性模型（ = 0.001）中，rs4919510多态性与结直肠癌风险降低显著相关，亚组分析还显示在杂合子模型中rs4919510多态性与甲状腺乳头状癌风险增加之间的相关性减弱（ = 0.04）。此外，癌症患者中rs4919510变异的预后显示，在纯合子模型中rs4919510 GG基因型与无复发生存期较差显著相关（ = 0.04）。荟萃分析表明，微小RNA - 608 rs4919510多态性可能与结直肠癌风险显著降低相关。需要对更大规模人群进行进一步研究以评估和确认这种关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0440/6046227/7e54531f604b/aging-10-101476-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0440/6046227/7349414b03f5/aging-10-101476-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0440/6046227/046bf98d93b9/aging-10-101476-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0440/6046227/8800924b0c8a/aging-10-101476-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0440/6046227/02f569b411d5/aging-10-101476-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0440/6046227/7e54531f604b/aging-10-101476-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0440/6046227/7349414b03f5/aging-10-101476-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0440/6046227/046bf98d93b9/aging-10-101476-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0440/6046227/8800924b0c8a/aging-10-101476-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0440/6046227/02f569b411d5/aging-10-101476-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0440/6046227/7e54531f604b/aging-10-101476-g005.jpg

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