Amiriani Taghi, Besharat Sima, Pourramezan Zahra, Mirkarimi Honey Sadat, Aghaei Mehrdad, Joshaghani Hamidreza, Roshandel Gholamreza, Faghani Maryam, Besharat Mahsa
1. Assistant Professor, Golestan University of Medical Sciences, Golestan Research Center of Gastroenterology and Hepatology, Gorgan, Iran.
2. Digestive Disease Research Institute, Tehran University of Medical Sciences, Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Iran.
Middle East J Dig Dis. 2015 Jan;7(1):25-30.
BACKGROUND Different clinical and epidemiological studies using dual-energy X-ray absorptiometry have shown an increased prevalence of low bone mineral density in patients with inflammatory bowel diseases. The aim of this study was to assess the correlation between bone density and the disease activity in patients with ulcerative colitis. METHODS In this cross-sectional study, 52 patients with ulcerative colitis (duration of the disease less than 5 years) were invited to our research center, Golestan province, northeast of Iran, during February 2012 up to August 2012. A demographic checklist and Simple Clinical Colitis Activity Index was completed for each patients and 5 cc of blood sample was taken after obtaining the informed consent. We used colorimetry method for measuring serum calcium, UV method for serum phosphorus and ELISA for serum vitamin D. Dual-energy X-ray absorptiometry was done to evaluate the bone density. Data analysis was done using SPSS software version 16. Normality of data was assessed using Kolmogorov- Smirnov test. T and ANOVA tests were used if data had normal distribution. Mann-Whitney U or Kruskal-Wallis tests were used for the remaining data. Correlation between qualitative variables was evaluated by Chi-square test. RESULTS The mean (±SD) age and disease activity of the patients were 37.72 (±12.18) years and 4.78 (±1.98), respectively. There were no correlation between disease activity and mean age. Low bone density was seen in 30.8%, 11.5%, and 15.4% in spine, femur neck, and hip, respectively. There was no relationship between Z-score of total hip, spine, and femur neck with disease activity, age, and duration of disease (p>0.05). CONCLUSION Our results showed an acceptable rate of low bone density in patients with ulcerative colitis without any correlation with the disease activity index.
不同的使用双能X线吸收法的临床和流行病学研究表明，炎症性肠病患者中低骨矿物质密度的患病率有所增加。本研究的目的是评估溃疡性结肠炎患者骨密度与疾病活动度之间的相关性。
在这项横断面研究中，2012年2月至2012年8月期间，邀请了52例溃疡性结肠炎患者（病程小于5年）到位于伊朗东北部戈勒斯坦省的我们的研究中心。为每位患者完成一份人口统计学清单和简单临床结肠炎活动指数，并在获得知情同意后采集5毫升血样。我们使用比色法测量血清钙，紫外法测量血清磷，酶联免疫吸附测定法测量血清维生素D。采用双能X线吸收法评估骨密度。使用SPSS软件16版进行数据分析。使用柯尔莫哥洛夫-斯米尔诺夫检验评估数据的正态性。如果数据呈正态分布，则使用t检验和方差分析。其余数据使用曼-惠特尼U检验或克鲁斯卡尔-沃利斯检验。通过卡方检验评估定性变量之间的相关性。
患者的平均（±标准差）年龄和疾病活动度分别为37.72（±12.18）岁和4.78（±1.98）。疾病活动度与平均年龄之间无相关性。脊柱、股骨颈和髋部的低骨密度分别见于30.8%、11.5%和15.4%的患者。全髋、脊柱和股骨颈的Z评分与疾病活动度、年龄和病程之间均无相关性（p>0.05）。
我们的结果显示，溃疡性结肠炎患者的低骨密度发生率可接受，且与疾病活动指数无任何相关性。
