Foroughi-Parvar Faeze, Hatam Gholamreza
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71347-45794, Iran.
Basic Sciences in Infectious Diseases Research Center, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz 71347-45794, Iran.
Adv Prev Med. 2014;2014:569193. doi: 10.1155/2014/569193. Epub 2014 Dec 31.
Leishmania infantum is the obligatory intracellular parasite of mammalian macrophages and causes zoonotic visceral leishmaniasis (ZVL). The presence of infected dogs as the main reservoir host of ZVL is regarded as the most important potential risk for human infection. Thus the prevention of canine visceral leishmaniasis (CVL) is essential to stop the current increase of the Mediterranean visceral leishmaniasis. Recently considerable advances in achieving protective immunization of dogs and several important attempts for achieving an effective vaccine against CVL lead to attracting the scientists trust in its important role for eradication of ZVL. This paper highlights the recent advances in vaccination against canine visceral leishmaniasis from 2007 until now.
婴儿利什曼原虫是哺乳动物巨噬细胞的专性细胞内寄生虫，可引起人畜共患内脏利什曼病（ZVL）。受感染的狗作为ZVL的主要储存宿主，被认为是人类感染的最重要潜在风险。因此，预防犬内脏利什曼病（CVL）对于阻止目前地中海内脏利什曼病的增加至关重要。最近，在实现犬类保护性免疫方面取得了相当大的进展，并且为研发针对CVL的有效疫苗进行了几次重要尝试，这使得科学家们相信其在根除ZVL方面的重要作用。本文重点介绍了2007年至今犬内脏利什曼病疫苗接种的最新进展。
