Vergne Isabelle, Gilleron Martine, Nigou Jérôme
Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique Toulouse, France ; Institut de Pharmacologie et de Biologie Structurale, Université Toulouse III - Paul Sabatier Toulouse, France.
Front Cell Infect Microbiol. 2015 Jan 12;4:187. doi: 10.3389/fcimb.2014.00187. eCollection 2014.
Lipoarabinomannan is a major immunomodulatory lipoglycan found in the cell envelope of Mycobacterium tuberculosis and related human pathogens. It reproduces several salient properties of M. tuberculosis in phagocytic cells, including inhibition of pro-inflammatory cytokine production, inhibition of phagolysosome biogenesis, and inhibition of apoptosis as well as autophagy. In this review, we present our current knowledge on lipoarabinomannan structure and ability to manipulate the endocytic pathway as well as phagocyte functions. A special focus is put on the molecular mechanisms employed and the signaling pathways hijacked. Available information is discussed in the context of M. tuberculosis pathogenesis.
脂阿拉伯甘露聚糖是一种主要的免疫调节性脂多糖，存在于结核分枝杆菌及相关人类病原体的细胞壁中。它在吞噬细胞中重现了结核分枝杆菌的几个显著特性，包括抑制促炎细胞因子的产生、抑制吞噬溶酶体的生物合成、抑制细胞凋亡以及自噬。在这篇综述中，我们介绍了目前关于脂阿拉伯甘露聚糖结构以及其操纵内吞途径和吞噬细胞功能能力的知识。特别关注了所采用的分子机制和被劫持的信号通路。在结核分枝杆菌发病机制的背景下讨论了现有信息。
