Silva Vanessa R, Soares Cristina B, Magalhães Juliana O, de Barcelos Isabella Peixoto, Cerqueira Debora C, Simões e Silva Ana Cristina, Oliveira Eduardo A
Nutrition Division, Hospital das Clínicas, Federal University of Minas Gerais (UFMG), 30130-100 Belo Horizonte, MG, Brazil.
Pediatric Nephrourology Unit, Department of Pediatrics, UFMG, 31270-901 Belo Horizonte, MG, Brazil.
ScientificWorldJournal. 2015;2015:810758. doi: 10.1155/2015/810758. Epub 2015 Jan 13.
This is longitudinal retrospective observational cohort study that evaluated anthropometric and biochemical variables of children and adolescents admitted to a Predialysis Interdisciplinary Management Program (PDIMP) responsible for the follow-up of children and adolescents at stages 2 to 4 of chronic kidney disease (CKD) at a tertiary center. One hundred thirty-eight patients with CKD on predialysis treatment with median age at admission of 9 years and the median follow-up time of 5 years were evaluated. Seventy-four (53%) had CKD stage 3 at admission and 70 (51%) reached CKD stage 5 at the end of the follow-up. There was no significant difference between the mean initial and final hemoglobin and serum albumin. However, the final serum bicarbonate presented a significant improvement. Analyses stratified according to clinical variables of interest showed a significant improvement in body mass index (BMI) Z score, especially in the subgroup of children admitted under two years of age. In relation to stature-for-age Z score, data show a significant improvement in stature SD at the end of the study. In conclusion, the present study showed improvement of nutritional status of CKD patients and that the deterioration of renal function was not correlated with BMI-for-age Z score.
这是一项纵向回顾性观察队列研究，评估了在一家三级中心参与透析前跨学科管理项目（PDIMP）的儿童和青少年的人体测量学和生化指标，该项目负责对处于慢性肾脏病（CKD）2至4期的儿童和青少年进行随访。对138例接受透析前治疗的CKD患者进行了评估，患者入院时的中位年龄为9岁，中位随访时间为5年。74例（53%）患者入院时处于CKD 3期，70例（51%）在随访结束时达到CKD 5期。初始和最终的血红蛋白及血清白蛋白均值之间无显著差异。然而，最终的血清碳酸氢盐水平有显著改善。根据感兴趣的临床变量进行分层分析显示，体重指数（BMI）Z评分有显著改善，尤其是在2岁以下入院的儿童亚组中。关于年龄别身高Z评分，数据显示研究结束时身高标准差有显著改善。总之，本研究表明CKD患者的营养状况有所改善，且肾功能恶化与年龄别BMI Z评分无关。
