de Carvalho-Ferreira Joana Pereira, Masquio Deborah Cristina Landi, da Silveira Campos Raquel Munhoz, Dal Molin Netto Bárbara, Corgosinho Flavia Campos, Sanches Priscila L, Tock Lian, Tufik Sergio, de Mello Marco Túlio, Finlayson Graham, Dâmaso Ana R
Post-Graduate Program of Interdisciplinary Health Sciences, Universidade Federal de São Paulo, Santos, SP, Brazil.
Post-Graduate Program of Nutrition - Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Peptides. 2015 Mar;65:20-8. doi: 10.1016/j.peptides.2014.11.010. Epub 2015 Jan 25.
Several studies have sought to clarify the association between adolescent obesity and psychological distress. Recently, a biological link between leptin resistance and depression has been proposed. The aim of the present study was to examine changes in leptin concentrations as a potential predictor of reduced depression symptoms in obese adolescents during long-term interdisciplinary weight loss therapy. Seventy-five obese adolescents (age: 16.28±2.37 years; BMI: 35.65±4.64 kg/m2) engaged in a long-term interdisciplinary therapy for weight loss. They were evaluated at baseline and after 1 year of treatment for body composition, serum analyses and depression symptomatology. After therapy, body mass BMI, fat mass (% and kg), waist circumference, visceral, subcutaneous and visceral/subcutaneous fat and depression symptoms decreased and lean mass (%) increased significantly. There was an improvement in inflammatory profiles with a significant reduction in leptin and increase in adiponectin. Regression analyses showed that decreased leptin predicted amelioration in depression symptoms independent of age, gender and changes in visceral fat, body mass, fat mass (%) and leptin/adiponectin ratio. These associations appear stronger in girls than boys. The attenuation of hyperleptinemia appears to play an important role in the association between weight loss and depression, particularly in obese girls.
多项研究试图阐明青少年肥胖与心理困扰之间的关联。最近，有人提出瘦素抵抗与抑郁症之间存在生物学联系。本研究的目的是检测瘦素浓度的变化，将其作为肥胖青少年在长期跨学科减肥治疗期间抑郁症状减轻的潜在预测指标。75名肥胖青少年（年龄：16.28±2.37岁；体重指数：35.65±4.64kg/m²）参与了一项长期跨学科减肥治疗。在基线期和治疗1年后，对他们进行了身体成分、血清分析和抑郁症状学评估。治疗后，体重指数、脂肪量（%和kg）、腰围、内脏脂肪、皮下脂肪和内脏/皮下脂肪比值以及抑郁症状均有所下降，瘦体重（%）显著增加。炎症指标有所改善，瘦素显著降低，脂联素增加。回归分析表明，瘦素降低可预测抑郁症状的改善，且不受年龄、性别以及内脏脂肪、体重、脂肪量（%）和瘦素/脂联素比值变化的影响。这些关联在女孩中似乎比男孩中更强。高瘦素血症的减轻似乎在减肥与抑郁症的关联中起重要作用，尤其是在肥胖女孩中。
