Orge Leonor, Machado Carla Guedes, Ramalho Luísa, Carvalho Renata, Silva João, Almeida Paula, Tavares Paula, Ochoa Cristina, Lima Carla, Pinto Maria J Marques, Simas J Pedro
a Laboratório de Patologia polos Benfica e Vairão; Instituto Nacional de Investigação Agrária e Veterinária, IP ; Lisboa e Vairão , Portugal.
Prion. 2015;9(1):22-8. doi: 10.1080/19336896.2014.997615. Epub 2015 Feb 10.
During the bovine spongiform encephalopathy (BSE) epidemic, Portugal was the third most affected country. As a result of a successful national eradication plan, the number of BSE affected animals has been progressively declining in Portugal with no cases identified in 2013. However, within the scope of this active surveillance scheme, we have identified the first H-type BSE case born after the introduction of the reinforced ban in fallen stock. Here, we report the phenotypic features of this case and the analysis of the protein coding sequence of prnp as well as the prnp promoter and intron 1 insertion-deletions.
在牛海绵状脑病（BSE）流行期间，葡萄牙是受影响第三严重的国家。由于一项成功的国家根除计划，葡萄牙感染BSE的动物数量一直在逐步下降，2013年未发现病例。然而，在这个主动监测计划的范围内，我们发现了在加强对死亡牲畜禁令实施后出生的首例H型BSE病例。在此，我们报告该病例的表型特征以及对prnp蛋白编码序列、prnp启动子和内含子1插入缺失的分析。
