Ojji Dike B, Opie Lionel H, Lecour Sandrine, Lacerda Lydia, Adeyemi Olusoji M, Sliwa Karen
Cardiology Unit, Department of Medicine, University of Abuja Teaching Hospital, Gwagwalada, Abuja; Hatter Institute for Cardiovascular Research in Africa, MRC Inter-Cape Heart Unit, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
Hatter Institute for Cardiovascular Research in Africa, MRC Inter-Cape Heart Unit, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
Cardiovasc J Afr. 2014 Sep-Oct;25(5):233-8. doi: 10.5830/CVJA-2014-050.
Although plasma NT-proBNP differentiates hypertension (HT) with or without left ventricular hypertrophy (LVH) from hypertensive heart failure (HHF), most of the published data are based on studies in Western populations. Also, most previous studies did not consider left ventricular (LV) diastolic function and right ventricular (RV) function. We therefore examined the relation between NT-proBNP on LV and RV remodelling in an African hypertensive cohort.
Subjects were subdivided into three groups after echocardiography: hypertensives without LVH (HT) (n = 83); hypertensives with LVH (HT + LVH) (n = 50); and those with hypertensive heart failure (HHF) (n = 77).
Subjects with HHF had significantly higher NT-proBNP levels compared to the HT + LVH group (p < 0.0002). NT-proBNP correlated positively with right atrial area, an indirect measure of RV function.
NT-proBNP is proposed as a useful biomarker in differentiating hypertension with or without LVH from hypertensive heart failure in black hypertensive subjects.
尽管血浆N末端脑钠肽前体（NT-proBNP）可区分有或无左心室肥厚（LVH）的高血压（HT）与高血压性心力衰竭（HHF），但大多数已发表的数据基于西方人群的研究。此外，大多数先前的研究未考虑左心室（LV）舒张功能和右心室（RV）功能。因此，我们在一个非洲高血压队列中研究了NT-proBNP与LV和RV重塑之间的关系。
经超声心动图检查后，将受试者分为三组：无LVH的高血压患者（HT）（n = 83）；有LVH的高血压患者（HT + LVH）（n = 50）；以及高血压性心力衰竭患者（HHF）（n = 77）。
与HT + LVH组相比，HHF患者的NT-proBNP水平显著更高（p < 0.0002）。NT-proBNP与右心房面积呈正相关，右心房面积是RV功能的间接指标。
NT-proBNP被认为是区分黑人高血压患者中有或无LVH的高血压与高血压性心力衰竭的有用生物标志物。
