Ferraioli Giovanna, Tinelli Carmine, Lissandrin Raffaella, Zicchetti Mabel, Faliva Milena, Perna Simone, Perani Guido, Alessandrino Francesco, Calliada Fabrizio, Rondanelli Mariangela, Filice Carlo
Departments of aInfectious Diseases, Ultrasound Unit bDiagnostic Imaging, Fondazione IRCCS Policlinico San Matteo, University of Pavia cClinical Epidemiology and Biometric Unit dDepartment of Internal Medicine, Fondazione IRCCS Policlinico San Matteo eDepartment of Applied Health Sciences, 'Santa Margherita' Rehabilitation Institute, University of Pavia, Pavia, Italy.
Eur J Gastroenterol Hepatol. 2015 Mar;27(3):305-12. doi: 10.1097/MEG.0000000000000287.
The aim of this study was to assess the clinical relevance of the controlled attenuation parameter (CAP) by analyzing the correlations between CAP and indirect indices of liver steatosis in obese or overweight individuals.
Consecutive participants were prospectively enrolled. BMI, waist circumference, hepatic steatosis index, fatty liver index, percent fat mass and regional fat masses as assessed by dual-energy X-ray absorptiometry (DXA), fat signal fraction as assessed by MRI, and CAP were obtained. Pearson's r coefficient was used to test the correlation between two study variables.
A total of 88 individuals were studied. They included 31 men [age, 50.4 years (12.9 years); BMI, 30.7 kg/m (4.8 kg/m)] and 57 women [age, 49.0 years (12.6 years); BMI, 31.4 kg/m (5.6 kg/m)]. DXA, anthropometric parameters, and fatty liver index were moderately correlated with CAP in men. In women, there was a moderate correlation of CAP with the hepatic steatosis index and anthropometric parameters and only a slight or fair correlation of CAP with DXA parameters. CAP and fat signal fraction showed a good correlation (r=0.65 in men, P=0.002; r=0.68 in women, P=0.0009).
Measurement of CAP is a reliable method for noninvasive assessment of liver steatosis, showing a correlation with other indirect markers of central obesity and a good correlation with MRI results.
本研究旨在通过分析肥胖或超重个体中受控衰减参数（CAP）与肝脂肪变性间接指标之间的相关性，评估CAP的临床相关性。
前瞻性纳入连续的参与者。获取体重指数（BMI）、腰围、肝脂肪变性指数、脂肪肝指数、双能X线吸收法（DXA）评估的体脂百分比和局部脂肪量、磁共振成像（MRI）评估的脂肪信号分数以及CAP。采用Pearson相关系数检验两个研究变量之间的相关性。
共研究了88名个体。其中包括31名男性[年龄，50.4岁（12.9岁）；BMI，30.7kg/m²（4.8kg/m²）]和57名女性[年龄，49.0岁（12.6岁）；BMI，31.4kg/m²（5.6kg/m²）]。在男性中，DXA、人体测量参数和脂肪肝指数与CAP呈中度相关。在女性中，CAP与肝脂肪变性指数和人体测量参数呈中度相关，而与DXA参数仅呈轻度或中度相关。CAP与脂肪信号分数显示出良好的相关性（男性r = 0.65，P = 0.002；女性r = 0.68，P = 0.0009）。
测量CAP是一种可靠的非侵入性评估肝脂肪变性的方法，与中心性肥胖的其他间接标志物相关，且与MRI结果具有良好的相关性。
