Sarwar Md Shahid, Sarkar Rakhesh Chandra, Bhowmick Rumpa, Dewan Syed Masudur Rahman, Ahmed Maizbha Uddin, Hasnat Abul, Rashid Mamunur, Islam Mohammad Safiqul
Department of Pharmacy, Southeast University , Banani, Dhaka , Bangladesh .
Hypertens Pregnancy. 2015 Feb;34(1):125-35. doi: 10.3109/10641955.2014.988349.
Increased extent of lipid peroxidation and decreased antioxidant defense has been postulated as a major contributor to the development of preeclampsia. The present study was conducted to determine the serum level of malondialdehyde (MDA) and vitamin C in these patients.
This research was conducted as a case-control study to assess the extent of lipid peroxidation and antioxidant status in 150 preeclampsia patients and 174 healthy pregnant women. Lipid peroxidation was assessed by measuring serum MDA level, and antioxidant defense was evaluated for serum vitamin C by UV spectrophotometric method. Independent sample t test and Pearson's correlation test were used for the statistical analysis with statistical software package SPSS, version 16.0 (SPSS, Inc., Chicago, IL).
Our study found significantly higher level of MDA (p < 0.05) and significantly lower level of vitamin C (p < 0.05) in preeclampsia patients in comparison to the control subjects. Pearson's correlation analysis revealed that there was negative correlation between the serum level of MDA and vitamin C for both patient (r = -0.057, p = 0.669) and control groups (r = -0.128, p = 0.487). Analysis of socio-economic data revealed that preeclampsia was more prevalent among the rural pregnant than the urban pregnant women (OR 1.44, 95% CI 0.665-3.14, p = 0.352). It was also observed that primigravida pregnant were at higher risk for the development of preeclampsia than the multigravida pregnant women (OR 1.87, 95% CI 0.868-4.04, p = 0.108).
Elevated serum MDA and depleted serum vitamin C may be associated with the development of preeclampsia.
脂质过氧化程度增加和抗氧化防御能力下降被认为是先兆子痫发病的主要因素。本研究旨在测定这些患者血清中丙二醛（MDA）和维生素C的水平。
本研究为病例对照研究，评估150例先兆子痫患者和174例健康孕妇的脂质过氧化程度和抗氧化状态。通过测定血清MDA水平评估脂质过氧化，采用紫外分光光度法评估血清维生素C的抗氧化防御能力。使用独立样本t检验和Pearson相关检验进行统计分析，统计软件为SPSS 16.0版（SPSS公司，伊利诺伊州芝加哥）。
我们的研究发现，与对照组相比，先兆子痫患者的MDA水平显著升高（p < 0.05），维生素C水平显著降低（p < 0.05）。Pearson相关分析显示，患者组（r = -0.057，p = 0.669）和对照组（r = -0.128，p = 0.487）的血清MDA水平与维生素C水平均呈负相关。社会经济数据分析显示，农村孕妇患先兆子痫的比例高于城市孕妇（比值比1.44，95%可信区间0.665 - 3.14，p = 0.352）。还观察到初产妇患先兆子痫的风险高于经产妇（比值比1.87，95%可信区间0.868 - 4.04，p = 0.108）。
血清MDA升高和血清维生素C缺乏可能与先兆子痫的发生有关。
