Kharb S, Gulati N, Singh V, Singh G P
Department of Biochemistry and Obstetrics and Gynaecology, Pt. Bhagwat Dayal Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.
Gynecol Obstet Invest. 1998;46(4):238-40. doi: 10.1159/000010041.
Twenty preeclamptic, 25 normotensive pregnant and 25 healthy nonpregnant women were analyzed with regard to serum malonaldehyde (MDA), vitamin E and lipid profile. In preeclampsia, MDA was significantly higher than control. MDA also showed high correlation to the level of blood pressure. Serum cholesterol and triglycerides were increased in normotensive women and still higher in preeclamptic women. A highly significant fall in vitamin E levels in preeclamptic women was noted as compared to control groups. Our study supports the view that an increased lipid peroxidation may be involved in vasoconstriction in preeclampsia.
对20例先兆子痫孕妇、25例血压正常的孕妇及25例健康非孕妇女的血清丙二醛（MDA）、维生素E和血脂水平进行了分析。先兆子痫患者的MDA水平显著高于对照组。MDA水平还与血压水平高度相关。血压正常的孕妇血清胆固醇和甘油三酯升高，先兆子痫孕妇的水平更高。与对照组相比，先兆子痫孕妇的维生素E水平显著下降。我们的研究支持以下观点：脂质过氧化增加可能参与了先兆子痫的血管收缩过程。
