Jochmans Ina, O'Callaghan John M, Pirenne Jacques, Ploeg Rutger J
Department of Microbiology and Immunology, Abdominal Transplantation, KU Leuven - University of Leuven, Leuven, Belgium.
Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium.
Transpl Int. 2015 Jun;28(6):665-76. doi: 10.1111/tri.12530. Epub 2015 Feb 12.
Hypothermic machine perfusion (HMP) of kidneys is a long-established alternative to static cold storage and has been suggested to be a better preservation method. Today, as our deceased donor profile continues to change towards higher-risk kidneys of lower quality, we are confronted with the limits of cold storage. Interest in HMP as a preservation technique is on the rise. Furthermore, HMP also creates a window of opportunity during which to assess the viability and quality of the graft before transplantation. The technology might also provide a platform during which the graft could be actively repaired, making it particularly attractive for higher-risk kidneys. We review the current evidence on HMP in kidney transplantation and provide an outlook for the use of the technology in the years to come.
肾脏低温机器灌注（HMP）是一种长期以来替代静态冷藏的方法，并且被认为是一种更好的保存方式。如今，随着我们的已故捐赠者情况持续朝着质量更低、风险更高的肾脏转变，我们面临着冷藏的局限性。对HMP作为一种保存技术的兴趣正在上升。此外，HMP还创造了一个机会窗口，在此期间可以在移植前评估移植物的活力和质量。该技术还可能提供一个平台，在此期间可以对移植物进行积极修复，这使得它对高风险肾脏特别有吸引力。我们回顾了目前关于肾脏移植中HMP的证据，并对该技术在未来几年的应用前景进行了展望。
