Belguendouz H, Messaoudene D, Lahmar-Belguendouz K, Djeraba Z, Otmani F, Terahi M, Tiar M, Hartani D, Lahlou-Boukoffa O S, Touil-Boukoffa C
USTHB, LBCM, équipe "cytokines et NO synthases", FSB, université Bab-Ezzouar, PB 32, 16111 Alger, Algeria.
USTHB, LBCM, équipe "cytokines et NO synthases", FSB, université Bab-Ezzouar, PB 32, 16111 Alger, Algeria.
J Fr Ophtalmol. 2015 Mar;38(3):206-12. doi: 10.1016/j.jfo.2014.10.005. Epub 2015 Jan 24.
Uveitis represents one of the major diagnostic criteria in Behçet's disease. It is most prevalent in the countries of the Mediterranean area, including Algeria, and along the Silk Road. Clinical features include oral and genital ulcers, ocular and skin lesions, as well as central nervous system, joint, vascular, gastrointestinal, or pulmonary manifestations. Many studies have reported that Th1 immune responses are involved in the physiopathology. We have previously studied the production of IL-12 and IFN-γ, cytokine markers in the Th1 pathway involved in Behçet's disease. In our study, we investigate in vivo and in vitro IL-18 production in Algerian patients with Behçet's disease with ocular manifestations in various stages of the disease. We examined the effect of glucocorticoids on IL-18 production during the active stage of the disease. Our results suggest that IL-18 could be a good biomarker for monitoring disease activity and its regression, demonstrating the effectiveness of treatment on the underlying immunopathologic process.
葡萄膜炎是白塞病的主要诊断标准之一。它在地中海地区国家最为普遍，包括阿尔及利亚，以及丝绸之路沿线国家。临床特征包括口腔和生殖器溃疡、眼部和皮肤病变，以及中枢神经系统、关节、血管、胃肠道或肺部表现。许多研究报告称，Th1免疫反应参与了其病理生理过程。我们之前研究了白塞病中Th1途径的细胞因子标志物IL-12和IFN-γ的产生。在我们的研究中，我们调查了阿尔及利亚有眼部表现的不同疾病阶段白塞病患者体内和体外IL-18的产生情况。我们研究了糖皮质激素在疾病活动期对IL-18产生的影响。我们的结果表明，IL-18可能是监测疾病活动及其消退的良好生物标志物，证明了治疗对潜在免疫病理过程的有效性。
