Lee Wan-Ru, Ishikawa Tomonori, Umetani Michihisa
Division of Pulmonary & Vascular Biology, Departments of Pediatrics & Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Division of Pulmonary & Vascular Biology, Departments of Pediatrics & Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA ; Comprehensive Reproductive Medicine, Graduate School of Medical & Dental Sciences, Tokyo Medical & Dental University, Tokyo, Japan.
Clin Lipidol. 2014;9(6):617-624. doi: 10.2217/clp.14.53.
Oxysterols are metabolites of cholesterol that are produced in liver and other peripheral tissues as a means to eliminate cholesterol to bile acid. Recent studies have revealed that the most abundant circulating oxysterol 27-hydroxycholesterol (27HC) is the first identified endogenous selective estrogen receptor modulator. 27HC levels correlate well with that of cholesterol, and also rise progressively with age. 27HC affects estrogen receptor function by the antagonism of estrogen action and also by the direct modulation of the receptor function, and similar to estrogen/estrogen receptors, 27HC has many actions in various tissues. This review article introduces the recent progress in the understanding of the role of 27HC in breast cancer and cardiovascular dysfunction.
氧化甾醇是胆固醇的代谢产物，在肝脏和其他外周组织中产生，作为将胆固醇转化为胆汁酸的一种方式。最近的研究表明，循环中最丰富的氧化甾醇27-羟基胆固醇（27HC）是首个被鉴定出的内源性选择性雌激素受体调节剂。27HC水平与胆固醇水平密切相关，并且也随着年龄的增长而逐渐升高。27HC通过拮抗雌激素作用以及直接调节受体功能来影响雌激素受体功能，并且与雌激素/雌激素受体类似，27HC在各种组织中具有多种作用。这篇综述文章介绍了在理解27HC在乳腺癌和心血管功能障碍中的作用方面的最新进展。
