由27-羟基胆固醇连接的新陈代谢、癌症和心血管疾病之间的相互作用。
The interaction between metabolism, cancer and cardiovascular disease, connected by 27-hydroxycholesterol.
作者信息
Lee Wan-Ru, Ishikawa Tomonori, Umetani Michihisa
机构信息
Division of Pulmonary & Vascular Biology, Departments of Pediatrics & Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Division of Pulmonary & Vascular Biology, Departments of Pediatrics & Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA ; Comprehensive Reproductive Medicine, Graduate School of Medical & Dental Sciences, Tokyo Medical & Dental University, Tokyo, Japan.
出版信息
Clin Lipidol. 2014;9(6):617-624. doi: 10.2217/clp.14.53.
Abstract
Oxysterols are metabolites of cholesterol that are produced in liver and other peripheral tissues as a means to eliminate cholesterol to bile acid. Recent studies have revealed that the most abundant circulating oxysterol 27-hydroxycholesterol (27HC) is the first identified endogenous selective estrogen receptor modulator. 27HC levels correlate well with that of cholesterol, and also rise progressively with age. 27HC affects estrogen receptor function by the antagonism of estrogen action and also by the direct modulation of the receptor function, and similar to estrogen/estrogen receptors, 27HC has many actions in various tissues. This review article introduces the recent progress in the understanding of the role of 27HC in breast cancer and cardiovascular dysfunction.
摘要
氧化甾醇是胆固醇的代谢产物，在肝脏和其他外周组织中产生，作为将胆固醇转化为胆汁酸的一种方式。最近的研究表明，循环中最丰富的氧化甾醇27-羟基胆固醇（27HC）是首个被鉴定出的内源性选择性雌激素受体调节剂。27HC水平与胆固醇水平密切相关，并且也随着年龄的增长而逐渐升高。27HC通过拮抗雌激素作用以及直接调节受体功能来影响雌激素受体功能，并且与雌激素/雌激素受体类似，27HC在各种组织中具有多种作用。这篇综述文章介绍了在理解27HC在乳腺癌和心血管功能障碍中的作用方面的最新进展。
相似文献
1
The interaction between metabolism, cancer and cardiovascular disease, connected by 27-hydroxycholesterol.由27-羟基胆固醇连接的新陈代谢、癌症和心血管疾病之间的相互作用。
Clin Lipidol. 2014;9(6):617-624. doi: 10.2217/clp.14.53.
2
Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-β, and ERβ: results from the EPIC-Heidelberg cohort.循环 27-羟胆固醇与 CYP27A1、CYP7B1、LXR-β 和 ERβ 在乳腺癌组织中的表达：来自 EPIC-Heidelberg 队列的研究结果。
Breast Cancer Res. 2020 Feb 19;22(1):23. doi: 10.1186/s13058-020-1253-6.
3
Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol.27-羟基胆固醇通过雌激素受体β介导对肺癌细胞增殖的调节
Front Endocrinol (Lausanne). 2018 Aug 23;9:470. doi: 10.3389/fendo.2018.00470. eCollection 2018.
4
Role of reactive oxygen species in regulating 27-hydroxycholesterol-induced apoptosis of hematopoietic progenitor cells and myeloid cell lines.活性氧在调节 27-羟胆固醇诱导造血祖细胞和髓系细胞系凋亡中的作用。
Cell Death Dis. 2022 Oct 31;13(10):916. doi: 10.1038/s41419-022-05360-0.
5
The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.胆固醇代谢物27-羟基胆固醇通过雌激素受体α介导的促炎过程促进动脉粥样硬化。
Cell Metab. 2014 Jul 1;20(1):172-82. doi: 10.1016/j.cmet.2014.05.013. Epub 2014 Jun 19.
6
27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator.27-羟基胆固醇，一种内源性选择性雌激素受体调节剂。
Maturitas. 2017 Oct;104:29-35. doi: 10.1016/j.maturitas.2017.07.014. Epub 2017 Jul 31.
7
Involvement of 27-hydroxycholesterol on the progression of non-small cell lung cancer via the estrogen receptor.27-羟基胆固醇通过雌激素受体参与非小细胞肺癌的进展
Am J Cancer Res. 2022 Sep 15;12(9):4241-4253. eCollection 2022.
8
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.27-羟基胆固醇是一种内源性选择性雌激素受体调节剂。
Mol Endocrinol. 2008 Jan;22(1):65-77. doi: 10.1210/me.2007-0383. Epub 2007 Sep 13.
9
Vitamin D supplementation decreases serum 27-hydroxycholesterol in a pilot breast cancer trial.维生素 D 补充剂可降低试点乳腺癌试验中的血清 27-羟胆固醇。
Breast Cancer Res Treat. 2018 Feb;167(3):797-802. doi: 10.1007/s10549-017-4562-4. Epub 2017 Nov 7.
10
Re-adopting classical nuclear receptors by cholesterol metabolites.胆固醇代谢产物对经典核受体的重新利用。
J Steroid Biochem Mol Biol. 2016 Mar;157:20-6. doi: 10.1016/j.jsbmb.2015.11.002. Epub 2015 Nov 10.
引用本文的文献
1
The Cytotoxicity of 27-Hydroxycholesterol in MCF-7 and MDA-MB-231.27-羟基胆固醇对MCF-7和MDA-MB-231细胞的细胞毒性
Adv Biomed Res. 2023 Oct 28;12:246. doi: 10.4103/abr.abr_13_23. eCollection 2023.
2
Oxysterols as Biomarkers of Aging and Disease.氧化固醇作为衰老和疾病的生物标志物。
Adv Exp Med Biol. 2024;1440:307-336. doi: 10.1007/978-3-031-43883-7_16.
3
Differences in Cholesterol Metabolism, Hepato-Intestinal Aging, and Hepatic Endocrine Milieu in Rats as Affected by the Sex and Age.胆固醇代谢、肝肠衰老和肝内分泌环境在大鼠中的性别和年龄差异。
Int J Mol Sci. 2023 Aug 10;24(16):12624. doi: 10.3390/ijms241612624.
4
Gene expressions between obligate bamboo-eating pandas and non-herbivorous mammals reveal converged specialized bamboo diet adaptation.强制性食竹大熊猫与非草食性哺乳动物之间的基因表达揭示了趋同的专门化竹食适应。
BMC Genomics. 2023 Jan 16;24(1):23. doi: 10.1186/s12864-023-09111-z.
5
Construction of a prognostic model of colon cancer patients based on metabolism-related lncRNAs.基于代谢相关长链非编码RNA构建结肠癌患者预后模型
Front Oncol. 2022 Sep 29;12:944476. doi: 10.3389/fonc.2022.944476. eCollection 2022.
6
Hormonal and Genetic Regulatory Events in Breast Cancer and Its Therapeutics: Importance of the Steroidogenic Acute Regulatory Protein.乳腺癌及其治疗中的激素和遗传调控事件：类固醇生成急性调节蛋白的重要性
Biomedicines. 2022 Jun 3;10(6):1313. doi: 10.3390/biomedicines10061313.
7
Association of demographic and health characteristics with circulating oxysterol concentrations.人口统计学和健康特征与循环氧化固醇浓度的关系。
J Clin Lipidol. 2022 May-Jun;16(3):345-355. doi: 10.1016/j.jacl.2022.03.012. Epub 2022 Apr 9.
8
Human Sex Matters: Y-Linked Lysine Demethylase 5D Drives Accelerated Male Craniofacial Osteogenic Differentiation.人类性别问题：Y 连锁赖氨酸去甲基化酶 5D 驱动加速男性颅面骨成骨分化。
Cells. 2022 Feb 26;11(5):823. doi: 10.3390/cells11050823.
9
PCSK9 Axis-Targeting Pseurotin A as a Novel Prostate Cancer Recurrence Suppressor Lead.靶向PCSK9轴的伪菌素A作为一种新型前列腺癌复发抑制先导物
ACS Pharmacol Transl Sci. 2021 Oct 5;4(6):1771-1781. doi: 10.1021/acsptsci.1c00145. eCollection 2021 Dec 10.
10
Our evolving understanding of how 27-hydroxycholesterol influences cancer.我们对 27-羟胆固醇如何影响癌症的认识不断发展。
Biochem Pharmacol. 2022 Feb;196:114621. doi: 10.1016/j.bcp.2021.114621. Epub 2021 May 24.
本文引用的文献
1
The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.胆固醇代谢物27-羟基胆固醇通过雌激素受体α介导的促炎过程促进动脉粥样硬化。
Cell Metab. 2014 Jul 1;20(1):172-82. doi: 10.1016/j.cmet.2014.05.013. Epub 2014 Jun 19.
2
Tumor macroenvironment and metabolism.肿瘤宏观环境与代谢。
Semin Oncol. 2014 Apr;41(2):281-95. doi: 10.1053/j.seminoncol.2014.02.005. Epub 2014 Mar 1.
3
The Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL/6J Mice.致肥胖饮食对C57BL/6J小鼠氧化甾醇代谢的影响
Cholesterol. 2014;2014:843468. doi: 10.1155/2014/843468. Epub 2014 Feb 5.
4
Human steroid and oxysterol 7α-hydroxylase CYP7B1: substrate specificity, azole binding and misfolding of clinically relevant mutants.人固醇和氧化固醇 7α-羟化酶 CYP7B1：底物特异性、唑类结合和临床相关突变体的错误折叠。
FEBS J. 2014 Mar;281(6):1700-13. doi: 10.1111/febs.12733. Epub 2014 Feb 20.
5
Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE-knockout mice.Cyp27A1 基因剂量对载脂蛋白 E 敲除小鼠动脉粥样硬化发展的影响。
FASEB J. 2014 Mar;28(3):1198-209. doi: 10.1096/fj.13-233791. Epub 2013 Dec 10.
6
27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.27-羟胆固醇将高胆固醇血症与乳腺癌病理生理学联系起来。
Science. 2013 Nov 29;342(6162):1094-8. doi: 10.1126/science.1241908.
7
De novo synthesis of steroids and oxysterols in adipocytes.脂肪细胞中类固醇和氧化甾醇的从头合成。
J Biol Chem. 2014 Jan 10;289(2):747-64. doi: 10.1074/jbc.M113.534172. Epub 2013 Nov 26.
8
27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth.27-羟胆固醇促进细胞自主的、ER 阳性乳腺癌生长。
Cell Rep. 2013 Nov 14;5(3):637-45. doi: 10.1016/j.celrep.2013.10.006. Epub 2013 Nov 7.
9
On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice.关于侧链羟化甾醇在大脑中的调节作用。来自 CYP27A1 转基因和 Cyp27a1(-/-) 小鼠的启示。
J Lipid Res. 2013 Apr;54(4):1033-43. doi: 10.1194/jlr.M034124. Epub 2013 Jan 2.
10
Relationships of coronary heart disease with 27-hydroxycholesterol, low-density lipoprotein cholesterol, and menopausal hormone therapy.冠心病与 27-羟胆固醇、低密度脂蛋白胆固醇和绝经激素治疗的关系。
Circulation. 2012 Sep 25;126(13):1577-86. doi: 10.1161/CIRCULATIONAHA.112.103218. Epub 2012 Aug 29.
Zotero 插件