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载万古霉素的聚甲基丙烯酸甲酯骨水泥联合超声及微泡介导超声的体外和体内评价

In vitro and in vivo evaluation of vancomycin-loaded PMMA cement in combination with ultrasound and microbubbles-mediated ultrasound.

作者信息

Lin Tiao, Cai Xun-Zi, Shi Ming-Min, Ying Zhi-Min, Hu Bin, Zhou Chen-He, Wang Wei, Shi Zhong-Li, Yan Shi-Gui

机构信息

Department of Orthopaedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China.

出版信息

Biomed Res Int. 2015;2015:309739. doi: 10.1155/2015/309739. Epub 2015 Jan 6.

DOI:10.1155/2015/309739
PMID:25632389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4302969/
Abstract

Ultrasound (US) has been used to increase elution of antibiotic from an antibiotic-loaded poly(methyl methacrylate) (PMMA) bone cement (ALBC). We aimed to further investigate whether microbubbles-mediated US (US + MB) facilitate elution of vancomycin (VAN) from cylindrical specimens and enhance the activity of the eluted antibiotic against Staphylococcus aureus (S. aureus) in vitro. The study groups comprised cylindrical bone cement fabricated with VAN (VAN), ALBC using US (VAN + US), and ALBC using MB-mediated US (VAN + US + MB). We also carried out an in vivo study involving the activity of VAN from cylindrical cement implanted in tibiae of New Zealand white rabbits inoculated with S. aureus. We found that (1) in vitro, elution from VAN + US + MB cylinders was significantly higher than from either the VAN or VAN + US specimens; (2) the activity of the eluted VAN from the VAN + US + MB cylinders against planktonic S. aureus was significantly higher than from either the control or VAN or VAN + US specimens; and (3) in the rabbits, the activity of the eluted VAN from the VAN + US + MB cylinders against S. aureus was significantly higher than from either the control or VAN or VAN + US specimens. The present results suggest that VAN-loaded PMMA cement irradiated with MB-mediated US may have a role in controlling prosthetic joint infection.

摘要

超声（US）已被用于增加抗生素从载有抗生素的聚甲基丙烯酸甲酯（PMMA）骨水泥（ALBC）中的洗脱量。我们旨在进一步研究微泡介导的超声（US + MB）是否能促进万古霉素（VAN）从圆柱形标本中洗脱，并增强洗脱后的抗生素在体外对金黄色葡萄球菌（S. aureus）的活性。研究组包括用VAN制备的圆柱形骨水泥（VAN）、使用US的ALBC（VAN + US）以及使用MB介导的US的ALBC（VAN + US + MB）。我们还进行了一项体内研究，涉及植入接种了金黄色葡萄球菌的新西兰白兔胫骨的圆柱形骨水泥中VAN的活性。我们发现：（1）在体外，VAN + US + MB圆柱体的洗脱量显著高于VAN或VAN + US标本；（2）VAN + US + MB圆柱体洗脱的VAN对浮游金黄色葡萄球菌的活性显著高于对照、VAN或VAN + US标本；（3）在兔子体内，VAN + US + MB圆柱体洗脱的VAN对金黄色葡萄球菌的活性显著高于对照、VAN或VAN + US标本。目前的结果表明，用MB介导的US照射载有VAN的PMMA骨水泥可能在控制人工关节感染方面发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a7/4302969/569794ebf2ab/BMRI2015-309739.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a7/4302969/87272b35a06f/BMRI2015-309739.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a7/4302969/7ffa5268cca4/BMRI2015-309739.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a7/4302969/2da3ec12961f/BMRI2015-309739.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a7/4302969/569794ebf2ab/BMRI2015-309739.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a7/4302969/87272b35a06f/BMRI2015-309739.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a7/4302969/7ffa5268cca4/BMRI2015-309739.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a7/4302969/2da3ec12961f/BMRI2015-309739.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a7/4302969/569794ebf2ab/BMRI2015-309739.004.jpg

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