Wei Huimin, Tao Yanfei, Chen Dongmei, Xie Shuyu, Pan Yuanhu, Liu Zhenli, Huang Lingli, Yuan Zonghui
a MOA Key Laboratory for Detection of Veterinary Drug Residues , Huazhong Agricultural University , Wuhan , Hubei , China.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(5):686-701. doi: 10.1080/19440049.2015.1008588. Epub 2015 Mar 2.
A rapid multi-residue screening method that includes 128 veterinary anti-parasitic drugs and metabolites in meat of chicken, porcine and bovine has been developed. The scope of the method focuses on screening the following main families of veterinary anti-parasitic drugs: avermectines, benzimidazoles, the polyether ionophore, anti-tapeworm, anti-trematode, anti-piroplasmosis and chemical classes of coccodiostats. The method described a QuEChERS sample preparation procedure prior to LC-MS/MS analysis. The modified QuEChERS technology minimises sample complexity and ion suppression effects. The method was validated according to European Union guidelines (2002/657/EC) for a quantitative screening method. The validation results demonstrate that the described LC-MS/MS method provides sensitive, repeatable and meets residue screening monitoring requirements.
已开发出一种快速多残留筛查方法，可检测鸡肉、猪肉和牛肉中128种兽用抗寄生虫药物及其代谢物。该方法的范围集中于筛查以下主要兽用抗寄生虫药物类别：阿维菌素、苯并咪唑、聚醚离子载体、抗绦虫药、抗吸虫药、抗梨形虫药以及抗球虫药的化学类别。该方法描述了在LC-MS/MS分析之前的QuEChERS样品制备程序。改良的QuEChERS技术可将样品复杂性和离子抑制效应降至最低。该方法根据欧盟定量筛查方法指南（2002/657/EC）进行了验证。验证结果表明，所描述的LC-MS/MS方法具有灵敏性、可重复性，且符合残留筛查监测要求。
